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Global Contrast-Enhanced Ultrasound (CEUS)

Click on any country shaded in orange to see the commercially available agent(s). Zoom to see smaller countries.
 

(Agent(s) commercially available)

 

 

(No agent commercially available at this time)

 

* See package inserts for approved indications. Note that this “Global CEUS” map lists certain ultrasound contrast agents under different product names (i.e., Lumason/SonoVue and Definity/Luminity). ICUS will update this map as additional agents are approved throughout the world.

 

ICUS does not endorse or recommend the use of any ultrasound contrast agent or other medical product. In addition, ICUS does not warrant the accuracy of information provided in package inserts or herein. Medical decisions are the sole responsibility of health care providers and their patients, who are encouraged to carefully evaluate all potential risks and benefits associated with the use of any medical product or procedure including ultrasound contrast agents and (CEUS).


Preoperative Contrast-Enhanced Ultrasound (CEUS) Combined with 125I Seeds Localization in Sentinel Lymph Node Biopsy for Breast Cancer

Preoperative Contrast-Enhanced Ultrasound (CEUS) Combined with 125I Seeds Localization in Sentinel Lymph Node Biopsy for Breast Cancer

February 24, 2021 — Dovepress
Abstract
Objective: To assess the clinical value of contrast-enhanced ultrasound (CEUS) technology in predicting axillary lymph nodes status before surgery, and to explore the feasibility of sentinel lymph nodes (SLNs) localization guided by CEUS combined with 125I implantation for breast cancer.
Methods: From August 2017 to February 2019, 115 patients were included in this prospective study. Before surgery, a microbubble (SonoVue) was injected intradermally next to the areola. The enhancement patterns of SLNs were recorded and 125I seeds (read more…)

5 Key Trends in Ultrasound Systems

5 Key Trends in Ultrasound Systems

Recent advances in ultrasound image systems include AI, automation, POCUS and development of therapeutic systems
February 18, 2021 — Imaging Technology News
Abstract
Recent advances in ultrasound image systems seen over the past year include the integration of artificial intelligence (AI), automation of functions and measurements, introduction of very specialized tool sets, the rapid growth in point-of-care systems, improved ergonomics, and on the horizon, the development of therapeutic ultrasound systems for cardiovascular and cancer therapies. These trends are highlighted in the breakout sections (read more…)

SRU CEUS Guidelines for Non-Cardiac Imaging

SRU CEUS Guidelines for Non-Cardiac Imaging

Contrast Enhanced Ultrasound, State of the Art in North America
Ultrasound Quarterly 
Authors; Richard Barr, et al
Guidelines for non-cardiac CEUS, published as a SRU white paper in September 2020 and reported subsequently in the ICUS Weekly News Monitor, are now included on the ICUS website.
Visit icus-society.org and click on ‘Body Imaging’ for liver, renal and bowel imaging.

Sonoporation: Underlying Mechanisms and Applications in Cellular Regulation

Sonoporation: Underlying Mechanisms and Applications in Cellular Regulation

February 6, 2021 — BIO Integration
Abstract
Ultrasound combined with microbubble-mediated sonoporation has been applied to enhance drug or gene intracellular delivery. Sonoporation leads to the formation of openings in the cell membrane, triggered by ultrasound-mediated oscillations and destruction of microbubbles. Multiple mechanisms are involved in the occurrence of sonoporation, including ultrasonic parameters, microbubbles size, and the distance of microbubbles to cells. Recent advances are beginning to extend applications through the assistance of contrast agents, which allow ultrasound to connect directly to (read more…)

Neuronavigation-guided focused ultrasound for transcranial blood-brain barrier opening and immunostimulation in brain tumors

Neuronavigation-guided focused ultrasound for transcranial blood-brain barrier opening and immunostimulation in brain tumors

February 5, 2021 — Science Advances
Abstract
Focused ultrasound (FUS) in the presence of microbubbles can transiently open the blood-brain barrier (BBB) to increase therapeutic agent penetration at the targeted brain site to benefit recurrent glioblastoma (rGBM) treatment. This study is a dose-escalating pilot trial using a device combining neuronavigation and a manually operated frameless FUS system to treat rGBM patients. The safety and feasibility were established, while a dose-dependent BBB-opening effect was observed, which reverted to baseline within 24 hours after (read more…)

The Application of Contrast Enhanced Ultrasound for Core Needle Biopsy of Subpleural Pulmonary Lesions: Retrospective Analysis in 92 Patients

The Application of Contrast Enhanced Ultrasound for Core Needle Biopsy of Subpleural Pulmonary Lesions: Retrospective Analysis in 92 Patients

February 2, 2021
Abstract
The purpose of this study was to investigate the role of contrast-enhanced ultrasound (CEUS) in determining the viable target area in patients with subpleural pulmonary lesions before ultrasound-guided transthoracic core biopsy. In this retrospective study, we analyzed 92 patients with subpleural pulmonary lesions (63 males and 29 females; mean age: 65.17 ± 11.72 y). All patients underwent B-mode ultrasound, color Doppler and CEUS. Color Doppler was performed to identify the major vessels. The time to enhancement of the (read more…)

Clinical Utility of Contrast-enhanced Ultrasound for the Diagnosis of Lymphadenopathy

Clinical Utility of Contrast-enhanced Ultrasound for the Diagnosis of Lymphadenopathy

January 21, 2021 — Ultrasound in Medicine and Biology
Abstract
This meta-analysis aimed to evaluate the diagnostic accuracy of contrast-enhanced ultrasonography (CEUS) in identifying lymphazdenopathy. PubMed, Web of Science, Embase and the Cochrane Library were searched for relevant articles through September 2020. A total of 16 articles, which included 1787 participants, were analyzed. The summary sensitivity, specificity, positive likelihood ratio (LR), negative LR and diagnostic odds ratio of CEUS for diagnosing lymphadenopathy were 0.88 (0.86–0.90), 0.90 (0.88–0.92), 6.04 (3.67–9.95), 0.15 (0.10–0.21) and (read more…)

Perfusion patterns of peripheral pulmonary lesions in COVID‐19 patients using contrast‐enhanced ultrasound (CEUS)

Perfusion patterns of peripheral pulmonary lesions in COVID‐19 patients using contrast‐enhanced ultrasound (CEUS)

January 18, 2021 — Journal of Ultrasound in Medicine
Abstract
Purpose
To describe perfusion patterns of peripheral pulmonary lesions (PPLs) in COVID‐19 patients using contrast‐enhanced ultrasound (CEUS).
Patients and methods
From April 2020 until July 2020, 11 consecutive patients with RT‐PCR‐confirmed COVID‐19 and PPLs sized over 5 mm were investigated by B‐mode ultrasound (B‐US) and CEUS. The homogeneity of enhancement (homogeneous and inhomogeneous) was examined retrospectively using CEUS. An inhomogeneous enhancement was defined as a perfused lesion with coexisting non‐perfused areas (NPA).
Results
On B‐US, all 11 patients (read more…)

New Applications in Echocardiography for Ultrasound Contrast Agents in the 21st Century

New Applications in Echocardiography for Ultrasound Contrast Agents in the 21st Century

January 8, 2020 — Ultrasound in Medicine and Biology
Abstract
Contrast echocardiography microbubbles are ultrasound-enhancing agents that were originally designed to help improve endocardial border definition, known as left ventricle opacification, and to enhance Doppler signals. Over time, contrast microbubbles are used to assess myocardial perfusion because they travel through the capillaries of the cardiac circulation. Current research provides good evidence that myocardial per-fusion echocardiography improves comprehensive echocardiographic evaluations of ischemic heart disease. The approval of regulatory authorities and the availability of (read more…)

Microbubbles Augment RT in Liver Cancer Patients

Microbubbles Augment RT in Liver Cancer Patients

December 31, 2020 — MedImaging.net
By Staff writers
A new study suggests that bursting gas-filled microbubbles using ultrasound waves sensitizes liver tumors to targeted radiation therapy (RT), improving overall survival.
Researchers at Thomas Jefferson University (TJU; Philadelphia, PA, USA) conducted a pilot study involving 28 patients (mean age 70 years, 17 men) with hepatocellular carcinoma (HCC), who were randomly assigned to trans-arterial radioembolization (TARE), or TARE in conjunction with ultrasound-triggered destruction of microbubbles (UTMD). The researchers evaluated tumor response to each treatment. (read more…)