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Global Contrast-Enhanced Ultrasound (CEUS)

Click on any country shaded in orange to see the commercially available agent(s). Zoom to see smaller countries.
 

(Agent(s) commercially available)

 

 

(No agent commercially available at this time)

 

* See package inserts for approved indications. Note that this “Global CEUS” map lists certain ultrasound contrast agents under different product names (i.e., Lumason/SonoVue and Definity/Luminity). ICUS will update this map as additional agents are approved throughout the world.

 

ICUS does not endorse or recommend the use of any ultrasound contrast agent or other medical product. In addition, ICUS does not warrant the accuracy of information provided in package inserts or herein. Medical decisions are the sole responsibility of health care providers and their patients, who are encouraged to carefully evaluate all potential risks and benefits associated with the use of any medical product or procedure including ultrasound contrast agents and (CEUS).


Value of Conventional Ultrasonography with Contrast-Enhanced Ultrasonography in the Differential Diagnosis of Partial Cystic Thyroid Nodules

Value of Conventional Ultrasonography with Contrast-Enhanced Ultrasonography in the Differential Diagnosis of Partial Cystic Thyroid Nodules

September 1, 2021 — Ultrasound in Medicine and Biology
Abstract
The value of contrast-enhanced ultrasonography (CEUS) in the diagnosis of malignant partial cystic thyroid nodules (PCTNs) remains unclear. Thus, in the present study, the data of patients with pathologically proven PCTNs who underwent CEUS in the Chinese PLA General Hospital from January 2016 to February 2019 were retrospectively reviewed, and the imaging characteristics of benign and malignant PCTNs were compared. A total of 177 PCTNs were enrolled in this study, including 58 (read more…)

Low-Intensity Focused Ultrasound Safe, Effective in Mild Alzheimer’s Disease

Low-Intensity Focused Ultrasound Safe, Effective in Mild Alzheimer’s Disease

August 30, 2021 — Medscape
By Pauline Anderson
A new noninvasive procedure is safe and effective for treating patients with mild Alzheimer’s disease (AD), new research suggests.
The approach uses MRI-guided low-intensity focused ultrasound (FUS) and injected microbubbles to temporarily open the blood-brain barrier (BBB).
In a small group of patients, the procedure was significantly associated with reduced amyloid plaque and cognitive decline.
Being able to cross the BBB “on demand” and in a safe way opens up numerous frontiers for treating not only AD (read more…)

Value of contrast-enhanced harmonic endoscopic ultrasound for diagnosing hepatic metastases of pancreatic cancer: A prospective study

Value of contrast-enhanced harmonic endoscopic ultrasound for diagnosing hepatic metastases of pancreatic cancer: A prospective study

August 17, 2021 — Journal of Gastroenterology and Hepatology
Abstract
Background and Aims
This study aimed to compare contrast-enhanced harmonic endoscopic ultrasound (CH-EUS) with fundamental B-mode endoscopic ultrasonography (EUS) and contrast-enhanced computed tomography (CE-CT) for the diagnosis of left hepatic lobe metastases of pancreatic adenocarcinoma.
Methods
In this single-center prospective study, CE-CT, EUS, and CH-EUS were performed to detect left hepatic lobe metastases in patients with pancreatic adenocarcinoma, and the detection rates were compared between EUS plus CH-EUS and the other two modalities. Subgroup comparisons (read more…)

Assessment of Microcirculation in the Type 2 Diabetic and Impaired Glucose Tolerance Feet of Elderly Men by CEUS

Assessment of Microcirculation in the Type 2 Diabetic and Impaired Glucose Tolerance Feet of Elderly Men by CEUS

August 11, 2021 — Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Objective
To evaluate the foot microcirculation in type 2 diabetes mellitus (T2DM) and impaired glucose tolerance patients (IGT) with contrast-enhanced ultrasound (CEUS).
Methods
The study included 37 patients with T2DM but without diabetic foot (DM group), 15 patients with impaired glucose tolerance (IGT group) and 10 elderly males with normal fasting blood glucose (FBS) and negative glucose tolerance tests (control group). Color Doppler flow imaging (CDFI) and CEUS were performed on the (read more…)

Longitudinal Changes in Knee Joint Synovial Vascularity in a Rabbit Model of Rheumatoid Arthritis: Quantification Using Power Doppler Ultrasound and Contrast-Enhanced Ultrasound

Longitudinal Changes in Knee Joint Synovial Vascularity in a Rabbit Model of Rheumatoid Arthritis: Quantification Using Power Doppler Ultrasound and Contrast-Enhanced Ultrasound

August 30, 2021 — Ultrasound in Medicine and Biology
Abstract
We studied a rabbit model of rheumatoid arthritis (RA) to examine the time course of changes in synovial neovascularization based on quantitative power Doppler ultrasound and contrast-enhanced ultrasound (CEUS). Twenty-five male New Zealand rabbits were in the ovalbumin-induced arthritis (OIA) group, and 5 were in the control group. Both rear knee joints of all rabbits were examined using conventional US and CEUS over 16 weeks. The knee synoviums of OIA rabbits were (read more…)

Contrast mammography plus ultrasound on par with MRI for preop staging

Contrast mammography plus ultrasound on par with MRI for preop staging

August 5, 2021 — AuntMinnie.com
By Amerigo Allegretto
A combination of contrast-enhanced mammography with ultrasound performs as well as breast MRI for preoperative staging for breast cancer, according to a Dutch study published August 2 in the European Journal of Radiology.
The study findings suggest that an effective “one-stop-shop” imaging strategy is available to clinicians and their breast cancer patients, wrote a group led by first author Dr. M.B.I. Lobbes from Zuyderland Medical Center in the Netherlands.
“Breast MRI is hardly necessary when (read more…)

Comparison of Magnetic Resonance Imaging and Contrast-Enhanced Ultrasound as Diagnostic Options for Unclear Cystic Renal Lesions: A Cost-Effectiveness Analysis

Comparison of Magnetic Resonance Imaging and Contrast-Enhanced Ultrasound as Diagnostic Options for Unclear Cystic Renal Lesions: A Cost-Effectiveness Analysis

August 3, 2021 — European Journal of Ultrasound
Abstract
Purpose
Correct differentiation between malignant and benign incidentally found cystic renal lesions has critical implications for patient management. In several studies contrast-enhanced ultrasound (CEUS) showed higher sensitivity with respect to the accurate characterization of these lesions compared to MRI, but the cost-effectiveness of CEUS has yet to be investigated. The aim of this study was to analyze the cost-effectiveness of CEUS as an alternative imaging method to MRI for the characterization of incidentally found (read more…)

Is CEUS the future for imaging complex renal cysts? Are we on the threshold of a change?

Is CEUS the future for imaging complex renal cysts? Are we on the threshold of a change?

August 3, 2021 — European Journal of Ultrasound – Editorial
Abstract
The paper by Gasser et al in this issue compares the cost-effectiveness of contrast-enhanced ultrasound (CEUS) with magnetic resonance (MR) imaging as a diagnostic option for indeterminate cystic renal lesions [1]. The cost-effectiveness of CEUS has also been investigated and reported recently by Spiesecke at al., adding contrast enhanced computed tomography (CECT) along with MR imaging, demonstrating the clear cost-effectiveness of CEUS [2]. An EFSUMB 2020 position statement, examining the evidence (read more…)

Role of CEUS in Vascular Pathology

Role of CEUS in Vascular Pathology

August 3, 2021 — European Journal of Ultrasound
Abstract
In recent years, the implementation of contrast-enhanced ultrasound (CEUS) in clinical practice has opened new horizons in the arterial pathologies research field, since this technique is able to supply new sets of data that can be crucial in patient management. The main applications of CEUS in the arterial system are the detection, characterization, and follow-up of carotid plaques and endoleaks after EVAR. Other situations in which CEUS was demonstrated to be a useful (read more…)

Contrast enhanced mammography (CEM) versus magnetic resonance imaging (MRI) for staging of breast cancer: The pro CEM perspective

Contrast enhanced mammography (CEM) versus magnetic resonance imaging (MRI) for staging of breast cancer: The pro CEM perspective

August 2, 2021 — European Journal of Radiology
Abstract
In women with newly diagnosed breast cancer, preoperative staging is required to assess disease extent, enabling us to decide on the most optimal treatment strategy. For locoregional staging, assessment of intramammary tumor extent and presence of axillary and perhaps also internal mammary lymph node metastases is required. Due to the similarity in the underlying principle, contrast-enhanced mammography is increasingly considered instead of breast MRI for this purpose. When considering the combination of CEM (read more…)