Global Contrast-Enhanced Ultrasound (CEUS)

Click on any country shaded in orange to see the commercially available agent(s).
 

(Agent(s) commercially available)

 

 

(No agent commercially available at this time)

 

* See package inserts for approved indications. Note that this “Global CEUS” map lists certain ultrasound contrast agents under different product names (i.e., Lumason/SonoVue and Definity/Luminity). ICUS will update this map as additional agents are approved throughout the world.

 

ICUS does not endorse or recommend the use of any ultrasound contrast agent or other medical product. In addition, ICUS does not warrant the accuracy of information provided in package inserts or herein. Medical decisions are the sole responsibility of health care providers and their patients, who are encouraged to carefully evaluate all potential risks and benefits associated with the use of any medical product or procedure including ultrasound contrast agents and (CEUS).


 

Ultrasound Imaging Finally Gets an Upgrade As Scientists Improve the Quality by 10x

Ultrasound Imaging Finally Gets an Upgrade As Scientists Improve the Quality by 10x

Oct 5, 2019 – Good News Network
Scientists have unveiled a new technique using a super-resolution ultrasound method that improves resolution by 5 to 10 times compared to standard ultrasound images.
The procedure, which allows whole organs to be scanned in super-resolution for the first time, is expected to lead to earlier cancer diagnoses and allow medical staff to more effectively target treatments to any malignant tissue. In fact, it could eventually replace the need for biopsy altogether.
Writing in the Journal of (read more…)

Ultrasound breakthrough ‘can spot cancer earlier’

Ultrasound breakthrough ‘can spot cancer earlier’

Sep 30, 2019 – BBC Scotland
By Kenneth Macdonald, BBC Scotland Science Correspondent
A new ultrasound technique is being hailed as the biggest breakthrough in the technology for more than 60 years. Developed at Heriot-Watt University in Edinburgh, it produces images that are 10 times better than current scans.
Researchers believe its ability to precisely pinpoint tumours could one day replace biopsies in investigating suspected cancer cases. The method, which is about to begin trials in human patients, uses existing scanning equipment.
In 1958, (read more…)

ICUS meeting highlights CEUS research

ICUS meeting highlights CEUS research

September 6, 2019 — AuntMinnie.com staff writers
The benefits of contrast-enhanced ultrasound (CEUS) are being highlighted at the International Contrast Ultrasound Society (ICUS) Bubble Conference in Chicago.
Among many other presentations, ICUS is highlighting the following research delivered at the conference:

A team led by Dr. Dirk-André Clevert of the University of Munich safely performed CEUS scans in pregnant women with suspected liver tumors.
A group led by Dr. Misun Hwang of the Children’s Hospital of Philadelphia used CEUS to diagnose brain injuries (read more…)

Resolution of indeterminate MRI with CEUS in patients at high risk for hepatocellular carcinoma

Resolution of indeterminate MRI with CEUS in patients at high risk for hepatocellular carcinoma

August, 2019 — Abdominal Radiology
Abstract
Purpose
To show the contribution of CEUS to characterization of indeterminate MRI observations in high-risk patients for hepatocellular carcinoma (HCC).
Methods
From July to December 2015, 42 consecutive patients referred to CEUS with indeterminate MRI scans comprise our study cohort. There are 50 indeterminate nodule-like observations and 10 arterial phase hyperenhancing foci, suggest-ing pseudolesions/arterio-portal shunts. MRI and CEUS lesions are classified according to their enhancement features in all phases and Liver Imaging and Reporting Data System (LI-RADS) in a (read more…)

CEUS augments limb perfusion

CEUS augments limb perfusion

Augmentation of Tissue Perfusion in Patients With Peripheral Artery Disease Using Microbubble Cavitation
JACC Cardiovascular Imaging — August, 2019
Abstract
Objectives
The authors investigated ideal acoustic conditions on a clinical scanner custom-programmed for ultrasound (US) cavitation-mediated flow augmentation in preclinical models. We then applied these conditions in a first-in-human study to test the hypothesis that contrast US can increase limb perfusion in normal subjects and patients with peripheral artery disease (PAD).
Background
US-induced cavitation of microbubble contrast agents augments tissue perfusion by convective shear and secondary (read more…)

Microbubble CEUS treatment in cervical cancer

Microbubble CEUS treatment in cervical cancer

The better effects of microbubble ultrasound transfection of miR-940 on cell proliferation inhibition and apoptosis promotion in human cervical cancer cells.
Dovepress — August 21, 2019
Purpose:
Cervical cancer is the second leading cause of women’s cancer-related death. MiR-940 has been reported as a critical factor in various cancers. Based on the high transfection efficiency and low side effect, the clinical application of microbubble ultrasound contrast agent in gene treatment has attracted a widespread attention. In this study, we determined the mechanism of (read more…)

Super-Resolution Contrast-Enhanced Ultrasound Methodology for the Identification of In Vivo Vascular Dynamics in 2D

Super-Resolution Contrast-Enhanced Ultrasound Methodology for the Identification of In Vivo Vascular Dynamics in 2D

August 2019 – Journal of Investigative Radiology
Abstract
Objectives
The aim of this study was to provide an ultrasound-based super-resolution methodology that can be implemented using clinical 2-dimensional ultrasound equipment and standard contrast-enhanced ultrasound modes. In addition, the aim is to achieve this for true-to-life patient imaging conditions, including realistic examination times of a few minutes and adequate image penetration depths that can be used to scan entire organs without sacrificing current super-resolution ultrasound imaging performance.
Methods
Standard contrast-enhanced ultrasound was used along with bolus (read more…)

Contrast Use in First Transthoracic Echocardiogram for Heart Failure Reduces Repeat Testing

Contrast Use in First Transthoracic Echocardiogram for Heart Failure Reduces Repeat Testing

August 7, 2019 — DAIC – Diagnostic and Interventional Cardiology
Study of more than 9,000 patients finds contrast group five times less likely to need repeat exam with earlier hospital discharge.
Heart failure is the fourth most common cause for all admission to U.S. hospitals, and it is the most common reason for ordering an inpatient transthoracic echocardiogram (TTE). Research presented at the 30th Annual American Society of Echocardiography (ASE) Scientific Sessions shows patients who received an echocardiogram with contrast were less (read more…)

Prostate Contrast Enhanced Transrectal Ultrasound (CE-TRUS) Evaluation of the Prostate with Whole Mount Prostatectomy Correlation.

Prostate Contrast Enhanced Transrectal Ultrasound (CE-TRUS) Evaluation of the Prostate with Whole Mount Prostatectomy Correlation.

August 6, 2019 — URO TODAY
To investigate the diagnostic accuracy of contrast enhanced transrectal ultrasound (CE-TRUS) in comparison with whole-mount radical prostatectomy specimens.
58 subjects who underwent CE-TRUS and subsequent radical prostatectomy with whole-mount pathology were included in the study. Each patient underwent evaluation with baseline TRUS and again during CE-TRUS with intravenous infusion of perflutren lipid microsphere (Definity®, Lantheus Medical Imaging, N Billerica, MA). A subjective 5 point scale was used to rate each sextant of the prostate in 3 (read more…)

Single-Center Study: Evaluating the Diagnostic Performance and Safety of Contrast-Enhanced Ultrasound (CEUS) in Pregnant Women to Assess Hepatic Lesions.

Single-Center Study: Evaluating the Diagnostic Performance and Safety of Contrast-Enhanced Ultrasound (CEUS) in Pregnant Women to Assess Hepatic Lesions.

July 30, 2019 — European Journal of Ultrasound
Abstract
Background:
Ultrasound is an essential imaging tool for evaluating physiological and pathological fetal or maternal conditions during pregnancy. Published data is limited with respect to the application of CEUS during pregnancy. CEUS has already been safely applied for assessing uteroplacental blood flow, cesarean scar pregnancy and invasive placenta percreta. CT and MRI scans during pregnancy must be thoroughly evaluated due to harmful ionizing radiation and cerebral gadolinium deposition, respectively.
Purpose:
The aim of the present retrospective (read more…)