ICUS urges FDA to Remove Boxed Warnings
on Ultrasound Contrast Agents;

Cites compelling scientific data demonstrating
their safety and life-saving potential.

Business Wire, August 31, 2020

To read full media release, click here.

To read the ICUS Citizen Petition, click here.



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ICUS webinars feature basic and advanced CEUS training for physicians, sonographers, nurses and other ultrasound professionals.

CLICK HERE for 2020 webinars with free CME

Basic and advanced CEUS training with free CME credit


CLICK HERE for additional CEUS webinars with free CME

Basic and advanced CEUS training with free CME credit


CLICK HERE FOR VIRTUAL EXHIBITS


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covid 19 ceus

The global COVID-19 pandemic presents unprecedented challenges for the ultrasound community, which often finds itself on the front lines of the battle against this deadly virus. Infected patients are often critically ill and require urgent bedside imaging of their lungs, heart and other organ systems. In this setting, ultrasound is uniquely capable of providing a safe, reliable and relatively inexpensive means of imaging these vulnerable patients, and the addition of an ultrasound enhancing agent may be essential for evaluating heart function.


ICUS is supporting the ultrasound community and patients worldwide by gathering the latest medical literature and training resources addressing the safe and optimal delivery of ultrasound services during this rapidly evolving global crisis. These resources include protocols for protecting personnel, disinfecting equipment, safely administering ultrasound contrast or enhancing agents, and appropriately imaging the heart, lungs and other organ systems in highly vulnerable patients.


CLICK HERE to learn more. Additional submissions may be sent to info@icus-society.org


The ICUS family extends heartfelt wishes for your safety and health as we come together to defeat this deadly virus.


Global Contrast-Enhanced Ultrasound (CEUS)

Click on any country shaded in orange to see the commercially available agent(s). Zoom to see smaller countries.
 

(Agent(s) commercially available)

 

 

(No agent commercially available at this time)

 

* See package inserts for approved indications. Note that this “Global CEUS” map lists certain ultrasound contrast agents under different product names (i.e., Lumason/SonoVue and Definity/Luminity). ICUS will update this map as additional agents are approved throughout the world.

 

ICUS does not endorse or recommend the use of any ultrasound contrast agent or other medical product. In addition, ICUS does not warrant the accuracy of information provided in package inserts or herein. Medical decisions are the sole responsibility of health care providers and their patients, who are encouraged to carefully evaluate all potential risks and benefits associated with the use of any medical product or procedure including ultrasound contrast agents and (CEUS).


 

Recent Advances on Ultrasound Contrast Agents for Blood-Brain Barrier Opening with Focused Ultrasound

Recent Advances on Ultrasound Contrast Agents for Blood-Brain Barrier Opening with Focused Ultrasound

November 21, 2020 — Pharmaceutics – Special Issue: Advances in Physics Methods for Drug Delivery
Abstract
The blood-brain barrier is the primary obstacle to efficient intracerebral drug delivery. Focused ultrasound, in conjunction with microbubbles, is a targeted and non-invasive way to disrupt the blood-brain barrier. Many commercially available ultrasound contrast agents and agents specifically designed for therapeutic purposes have been investigated in ultrasound-mediated blood-brain barrier opening studies. The new generation of sono-sensitive agents, such as liquid-core droplets, can also potentially disrupt the (read more…)

Comparison Between Below Knee Contrast Enhanced Tomographic 3D Ultrasound and CT, MR or Catheter Angiography for Peripheral Artery Imaging

Comparison Between Below Knee Contrast Enhanced Tomographic 3D Ultrasound and CT, MR or Catheter Angiography for Peripheral Artery Imaging

November 20, 2020 — European Journal of Vascular and Endovascular Surgery
Abstract
Objective
Clear imaging of below knee and foot arteries is essential to plan distal reconstructions. Contrast enhanced tomographic 3D ultrasound (CEtUS) is novel and entirely safe with no exposure to ionising radiation or nephrotoxic contrast. In the present study, inter- and intra-observer agreement of CEtUS was calculated, and compared with below knee angiography.
Methods
In the same week as computed tomography, magnetic resonance or catheter angiography, CEtUS was performed using intravenous 1.2 mL (read more…)

EMUC 2020: Ultrasound Is Improving: 29 Mhz, mpUS, C-TRUS, Elastography and Microbubble

EMUC 2020: Ultrasound Is Improving: 29 Mhz, mpUS, C-TRUS, Elastography and Microbubble

November 16, 2020 — UroToday.com
At the Fragments of Imaging session at the European Multidisciplinary Congress on Urological Cancers 2020 virtual meeting, Dr. Christophe Mannaerts discussed emerging roles for ultrasound as it relates to prostate cancer detection.
Dr. Mannaerts started by noting that greyscale ultrasound is not a reliable method for detecting prostate cancer, even though some tumors are visible as hypoechoic lesions. However, there are emerging novel ultrasound modalities for prostate cancer detection and localization, including C-Trus, contrast-enhanced ultrasound, shear (read more…)

Road to RSNA 2020 — Ultrasound: The 60-year-old modality of the future

Road to RSNA 2020 — Ultrasound: The 60-year-old modality of the future

November 10, 2020 — AuntMinnie
By Theresa Pablos
Read full text at: https://www.auntminnie.com/index.aspx?sec=road&sub=ult_2020&pag=dis&itemId=130717
Extract
Ultrasound has been around forever. It suffers from low resolution. It hasn’t had the same buzzworthy advancements seen in other imaging modalities. But that’s changing, thanks to new technologies redefining how ultrasound is performed — and who gets to perform it.
What’s the result? Leading radiologists are increasingly pointing to ultrasound as the imaging method of the future.
“There are a lot of interesting things happening that I hope will reelevate (read more…)

Diagnostic accuracy of grayscale, power Doppler and contrast-enhanced ultrasound compared with contrast-enhanced MRI in the visualization of synovitis in knee osteoarthritis

Diagnostic accuracy of grayscale, power Doppler and contrast-enhanced ultrasound compared with contrast-enhanced MRI in the visualization of synovitis in knee osteoarthritis

November 9, 2020 — DocWire News
Purpose: To assess the diagnostic accuracy of grayscale (GSUS), power Doppler (PDUS) and contrast-enhanced ultrasound (CEUS) for detecting synovitis in knee osteoarthritis (OA).
Method: Patients with different degrees of radiographic knee OA were included prospectively. All underwent GSUS, PDUS, CEUS, and contrast-enhanced magnetic resonance imaging (CE-MRI), on which synovitis was assessed semi-quantitatively. Correlations of synovitis severity on ultrasound based techniques with CE-MRI were determined. Receiver operating characteristic (ROC) analysis was performed to assess diagnostic performance of (read more…)

Contrast-Enhanced Ultrasonography versus Contrast-Enhanced Magnetic Resonance Imaging in the Diagnosis of Mediastinal Tumors

Contrast-Enhanced Ultrasonography versus Contrast-Enhanced Magnetic Resonance Imaging in the Diagnosis of Mediastinal Tumors

November 2, 2020 — Ultrasound in Medicine and Biology
Abstract
The aim of the study was to evaluate and compare contrast-enhanced ultrasound (CEUS)and contrast-enhanced magnetic resonance imaging (CE-MRI) with respect to their valuein the differential diagnosis between benign and malignant mediastinal tumors.
Method:  Forty-two patients with mediastinal tumor underwent CEUS and CE-MRI respectively. The sensitivity, specificity, diagnostic coincidence rate, positive predictive value (PPV) and negative predictive value of the two methods were compared. The value of different enhancement patterns in the differential diagnosis (read more…)

Ultrasound vs. MRI to detect uterine leiomyomas

Ultrasound vs. MRI to detect uterine leiomyomas

October 23, 2020 — Contemporary OB/GYN
By Bob Kronemyer
A prospective observational study in the Journal of Ultrasound in Medicine has concluded that for pretreatment evaluation of uterine fibroids (UF), transabdominal contrast-enhanced ultrasound (CEUS) represents a viable alternative to traditional contrast-enhanced magnetic resonance imaging (MRI).
CEUS also provides a test of choice in patients with a contraindication to MRI.
Said principal investigator Chris DeMauro, MD, chief of body imaging and director of ultrasound at Christiana Care Health Services in Newark, Delaware, “CEUS is an (read more…)

Utility of Targeted Ultrasound in Predicting Malignancy Among Lesions Detected on Contrast-Enhanced Digital Mammography

Utility of Targeted Ultrasound in Predicting Malignancy Among Lesions Detected on Contrast-Enhanced Digital Mammography

October 19, 2020 — American Journal of Roentgenology
Abstract
Background: Targeted ultrasound (US) can be performed to characterize and potentially biopsy areas of enhancement detected oncontrast-enhanced mammography (CEM).
Objective: To determine the utility of targeted US in predicting malignancy of indeterminate or suspicious enhancement on CEM.
Methods: 1000 consecutive CEM examinations with a same-day targeted breast US performed at our institution between October 2013 and May 2018 were retrospectively reviewed. All cases with indeterminate or suspicious enhancement detected on CEM that underwent US evaluation (read more…)

An Integrated Approach to Ultrasound Imaging in Medicine and Biology

An Integrated Approach to Ultrasound Imaging in Medicine and Biology

October 19, 2020 — Bio Integration
EurekAlert News Release
Announcing a new article publication for BIO Integration journal. In this editorial, Co-Editor-in-Chief, Pintong Huang considers an integrated approach to ultrasound imaging in medicine and biology.
Ultrasound imaging is an important method for clinical disease screening, early diagnosis, and non-invasive guidance. The development and research pertaining to ultrasound contrast agents for ultrasound molecular imaging underlies the advancement of ultrasound targeted technologies and is the driving force for the progression of ultrasound molecular imaging.
The utilization (read more…)

Special Collection of Papers from the 25th European Symposium on Ultrasound Contrast Imaging – A set of review articles covering the past, present and future of UCA

Special Collection of Papers from the 25th European Symposium on Ultrasound Contrast Imaging – A set of review articles covering the past, present and future of UCA

Journal of Ultrasound in Medicine and Biology
Open access via: https://www.umbjournal.org/us_contrast_imaging
Contrast-Enhanced High-Frame-Rate Ultrasound Imaging of Flow Patterns in Cardiac Chambers and Deep Vessels
Authors: Hendrik J. Vos, Jason D. Voorneveld, Erik Groot Jebbink, Chee Hau Leow, Luzhen Nie, Annemien E. van den Bosch, Meng-Xing Tang, Steven Freear, Johan G. Bosch
Ultrasound in Medicine and Biology, Vol. 46, Issue 11, p2875–2890

Ultrasound Contrast Agent Modeling: A Review
Authors: Michel Versluis, Eleanor Stride, Guillaume Lajoinie, Benjamin Dollet, Tim Segers
Ultrasound in Medicine and Biology, (read more…)