Contrast Agent Uses Heart’s Electricity to Activate Itself

Contrast Agent Uses Heart’s Electricity to Activate Itself

June 24, 2019 — Medgadget
Imaging the heart for signs of disease is still quite rudimentary. While CT, ultrasound, and PET (positron-emission tomography) scanners generate impressive looking graphics, they’re a long way from giving doctors a true representation of the anatomy and function of the heart and nearby vasculature.
Contrast agents are widely used to allow these modalities to produce better images of the heart, but they’re indiscriminate in what they help to illuminate. Similar to a flood light, these agents tend (read more…)

Lantheus touts contrast echo study at ASE 2019

Lantheus touts contrast echo study at ASE 2019

Jun 24, 2019 — AuntMinnie
By AuntMinnie.com staff writers
Lantheus Holdings, the parent company of Lantheus Medical Imaging, is directing attention to new clinical data for its Definity ultrasound contrast agent being presented June 24 at the American Society of Echocardiography (ASE) meeting in Portland, OR.
The researchers, led by Dr. Michael Main from Saint Luke’s Mid America Heart Institute in Kansas City, MO, examined the data of roughly 1.5 million intensive care unit (ICU) patients from 773 hospitals who underwent echocardiography (read more…)

Sonothrombolysis in ST-Segment Elevation Myocardial Infarction Treated With Primary Percutaneous Coronary Intervention

Sonothrombolysis in ST-Segment Elevation Myocardial Infarction Treated With Primary Percutaneous Coronary Intervention

June 2019 — Journal of the American College of Cardiology (JACC)
Abstract
Background Preclinical studies have demonstrated that high mechanical index (MI) impulses from a diagnostic ultrasound transducer during an intravenous microbubble infusion (sonothrombolysis) can restore epicardial and microvascular flow in acute ST-segment elevation myocardial infarction (STEMI).
Objectives
This study tested the clinical effectiveness of sonothrombolysis in patients with STEMI.
Methods
Patients with their first STEMI were prospectively randomized to either diagnostic ultrasound–guided high MI impulses during an intravenous Definity (Lantheus Medical Imaging, North Billerica, Massachusetts) (read more…)

‘Selfie mode’ for heart imaging could help doctors spot heart disease earlier

‘Selfie mode’ for heart imaging could help doctors spot heart disease earlier

June 13, 2019 — MedicalXpress
by Drexel University
*To be presented at the 34th Advances in Contrast Ultrasound International Bubble Conference in Chicago in September.
One of the reasons cardiovascular disease kills 610,000 Americans each year is that it’s hard to see it coming before it’s too late. By the time someone is experiencing chest pain, irreversible damage has likely been done. Despite advancements in medical imaging technology for the rest of the body, it’s still quite difficult to get a clear look (read more…)

Detecting Pancreatic Cancer

Detecting Pancreatic Cancer

Tucson Tech: World View touts success, growth
May 1, 2019 – Arizona Daily Star
Microvascular Therapeutics, a Tucson-based company co-founded by University of Arizona radiology professor Dr. Evan Unger, has licensed two patent applications from Stanford University to develop a new test for pancreatic cancer.
The company will marry an antibody for pancreatic cancer developed at Stanford with a new ultrasound imaging contrast agent, MVT-100, which is currently in clinical testing and is being supported by the National Heart, Lung, and Blood Institute, (read more…)

Can CEUS Increase or Predict the Success Rate of Testicular Sperm Aspiration in Patients With Azoospermia?

Can CEUS Increase or Predict the Success Rate of Testicular Sperm Aspiration in Patients With Azoospermia?

May, 2019 – American Journal of Roentgenology
ABSTRACT :
OBJECTIVE. The objective of our study was to determine whether contrast-enhanced ultrasound (CEUS) perfusion measurements obtained before testicular sperm aspiration (TESA) can improve or predict sperm retrieval (SR) outcomes of TESA in patients with azoospermia.
SUBJECTS AND METHODS. Between May 2017 and January 2018, 70 patients with azoospermia (mean age, 29 years; age range, 22–41 years) underwent testes CEUS within 10 days before TESA. Major perfusion areas were visually chosen, and their ranges were (read more…)

3D Super-Resolution US Imaging of Rabbit Lymph Node Vasculature in Vivo by Using Microbubbles

3D Super-Resolution US Imaging of Rabbit Lymph Node Vasculature in Vivo by Using Microbubbles

April, 2019 – Radiology
Background: Variations in lymph node (LN) microcirculation can be indicative of metastasis. The identification and quantification of metastatic LNs remains essential for prognosis and treatment planning, but a reliable noninvasive imaging technique is lacking. Three-dimensional super-resolution (SR) US has shown potential to noninvasively visualize microvascular networks in vivo.
Purpose: To study the feasibility of three-dimensional SR US imaging of rabbit LN microvascular structure and blood flow by using microbubbles.
Materials and Methods: In vivo studies were carried out to (read more…)

The way forward for vascular Surgeons

The way forward for vascular Surgeons

Tomographic 3D ultrasound imaging “the way forward” for vascular surgeons
24th April 2019 – Vascular News
Steven Rogers (Manchester, UK) presented the case for using contrast-enhanced tomographic 3D ultrasound imaging for peripheral arterial disease, telling the audience at Charing Cross Symposium (CX; 15–18 April, London, UK): “Our surgeons certainly prefer the 3D vein mapping to a 2D vein map”.
According to Rogers, tomographic 3D ultrasound imaging is “minimally-invasive, you can do it with relatively little experience, it is fast, it is inexpensive, it (read more…)

Utility of Complementary Magnetic Resonance Plaque Imaging and CEUS to Detect Carotid Vulnerable Plaques

Utility of Complementary Magnetic Resonance Plaque Imaging and CEUS to Detect Carotid Vulnerable Plaques

April 16, 2019 – Journal of the American Heart Association
Abstract
Background
We aimed to improve the assessment quality of plaque vulnerability with combined use of magnetic resonance imaging and contrast-enhanced ultrasound (CEUS).
Methods and Results
We prospectively enrolled 71 patients with internal carotid artery stenosis who underwent carotid endarterectomy and performed preoperative CEUS and magnetic resonance plaque imaging. We distinguished high–signal‐intensity plaques (HIPs) and non‐HIPs based on magnetization‐prepared rapid acquisition with gradient echo images. We graded them according to the CEUS contrast effect and (read more…)

Carotid intraplaque neovascularization predicts coronary artery disease and cardiovascular events

Carotid intraplaque neovascularization predicts coronary artery disease and cardiovascular events

European Society of Cardiology – European Heart Journal – April 12, 2019
Abstract
Aims
It is thought that the majority of cardiovascular (CV) events are caused by vulnerable plaque. Such lesions are rupture prone, in part due to neovascularization. It is postulated that plaque vulnerability may be a systemic process and that vulnerable lesions may co-exist at multiple sites in the vascular bed. This study sought to examine whether carotid plaque vulnerability, characterized by contrast-enhanced ultrasound (CEUS)-assessed intraplaque neovascu-larization (IPN), was associated with (read more…)