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ICUS ANYTIME is a comprehensive CEUS education portal
offering the convenience of online learning and free CME credits.

Learn basic and advanced CEUS from the experts!

CLICK HERE for upcoming live webinars

CLICK HERE for upcoming bubble conferences and other CEUS programs

CLICK HERE for archived ICUS webinars.


ICUS VIRTUAL EXHIBITS simulate the traditional exhibit experience
offered at live, in-person educational programs.

See how ultrasound products are used to improve CEUS and patient care.

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Global Contrast-Enhanced Ultrasound (CEUS)

Click on any country shaded in orange to see the commercially available agent(s). Zoom to see smaller countries.
 

(Agent(s) commercially available)

 

 

(No agent commercially available at this time)

 

* See package inserts for approved indications. Note that this “Global CEUS” map lists certain ultrasound contrast agents under different product names (i.e., Lumason/SonoVue and Definity/Luminity). ICUS will update this map as additional agents are approved throughout the world.

 

ICUS does not endorse or recommend the use of any ultrasound contrast agent or other medical product. In addition, ICUS does not warrant the accuracy of information provided in package inserts or herein. Medical decisions are the sole responsibility of health care providers and their patients, who are encouraged to carefully evaluate all potential risks and benefits associated with the use of any medical product or procedure including ultrasound contrast agents and (CEUS).


Parker Labs leads investment in Solstice ultrasound contrast agent

Parker Labs leads investment in Solstice ultrasound contrast agent

July 7, 2021 — AuntMinnie.com
By Staff writers
Parker Laboratories has led a consortium making an investment in Solstice Pharmaceuticals that’s designed to fund the company’s development of a new ultrasound contrast agent.
The agent is based on microbubble technology that allows image contrast to be precisely engineered and optimized with custom-made monodisperse microbubbles for use in a wide range of applications. It aims to enhance image contrast, improve diagnostic accuracy, and make ultrasound scanning more widely applicable.
Parker’s investment speeds up the (read more…)

Therapeutic Angiogenesis for Ovarian Transplantation through Ultrasound-Targeted Microbubble Destruction

Therapeutic Angiogenesis for Ovarian Transplantation through Ultrasound-Targeted Microbubble Destruction

July 1, 2021 — Ultrasound in Medicine and Biology
Abstract
Timely angiogenesis and effective microcirculation perfusion are essential for the survival and functional recovery of transplanted ovaries. Ultrasound-targeted microbubble destruction (UTMD) can lead to angiogenesis and increase flow perfusion by causing transient inflammation. The purpose of this study was to evaluate the effects of UTMD on transplanted ovarian revascularization and survival. In vitro, for the criteria of cell viability and tube formation capability, the optimal exposure parameters were determined to be a (read more…)

Principal component regression-based contrast-enhanced ultrasound evaluation system for the management of BI-RADS US 4A breast masses: objective assistance for radiologists

Principal component regression-based contrast-enhanced ultrasound evaluation system for the management of BI-RADS US 4A breast masses: objective assistance for radiologists

July 1,2021 — Ultrasound in Medicine and Biology
Abstract
A portion of detected breast masses might be overrated by using the Breast Imaging-Reporting and Data System ultrasonography (BI-RADS US) lexicon. A principal component regression-based contrast-enhanced ultrasound (PCR-CEUS) evaluation system was built to quantitatively illustrate whether CEUS could help radiologists to differentiate 4A masses. The PCR-CEUS evaluation system, based on principal component analysis (PCA) and logistic regression, was verified by random assignment into training and test sets and shown to reduce the data (read more…)

ANNOUNCING: New CEUS education hub for sonography schools

ANNOUNCING: New CEUS education hub for sonography schools

Free access to CEUS educational frameworks, webinars and other resources suitable for incorporation into the curricula of sonography training programs
Prepared by Joint Task Force on CEUS Curriculum in Sonographer Schools
July 1, 2021
ICUS
Access the Hub at: www.icus-society.org
Contrast Enhanced Ultrasound (CEUS) has been an essential component of modern ultrasound laboratories throughout the world for over two decades. It is, therefore, imperative that sonography training programs incorporate CEUS education in their curricula.
To that end, the Joint Task Force on CEUS Curriculum in (read more…)

Ultrasound Contrast Agents Greatly Aids in Complex Congenital Heart Imaging

Ultrasound Contrast Agents Greatly Aids in Complex Congenital Heart Imaging

June 29, 2021 — DAIC
By Editor
Echocardiography with ultrasound enhancing agents (UEAs) has proven to be a valuable imaging procedure after surgery for children born with single ventricle congenital heart disease (CHD). This heart defect occurs when one of the two ventricles is not large enough or strong enough to work correctly. Research presented at the American Society of Echocardiography (ASE) 2021 virtual meeting, June 18-21, highlights how echocardiography with UEAs in CHD patients post-operatively can improve diagnostic capabilities and decrease (read more…)

Quantitative ultrasound characterization of therapy response in prostate cancer in vivo

Quantitative ultrasound characterization of therapy response in prostate cancer in vivo

June 21, 2021 — DocWire News
Abstract
Quantitative ultrasound (QUS) is a non-invasive imaging modality that permits the detection of tumor response following various cancer therapies. Based on ultrasound signal scattering from the biological system, scatterer size, and concentration of microscopic scatterers, QUS enables the rapid characterization of tumor cell death. In this study, tumor response to ultrasound-stimulated microbubbles (USMB) and hyperthermia (HT) in tumor-bearing mice, with prostate cancer xenografts (PC3), was examined using QUS. Treatment conditions included 1% (v/v) Definity microbubbles (read more…)

Predicting Long-Term Hepatocellular Carcinoma Response to Transarterial Radioembolization Using Contrast-Enhanced Ultrasound: Initial Experiences

Predicting Long-Term Hepatocellular Carcinoma Response to Transarterial Radioembolization Using Contrast-Enhanced Ultrasound: Initial Experiences

June 13, 2021 — Ultrasound in Medicine and Biology
Abstract
Conventional cross-sectional imaging done shortly after radioembolization of hepatocellular carcinoma (HCC) does not reliably predict long-term response to treatment. This study evaluated whether quantitative contrast-enhanced ultrasound (CEUS) can predict the long-term response of HCC to yttrium-90 (Y-90) treatment. Fifteen patients underwent CEUS at three time points: immediately following treatment and 1 and 2 wk post-treatment. Response 3–6 mo after treatment was categorized on contrast-enhanced magnetic resonance imaging by two experienced radiologists using (read more…)

Pediatric contrast-enhanced ultrasound: shedding light on the pursuit of approval in the United States

Pediatric contrast-enhanced ultrasound: shedding light on the pursuit of approval in the United States

June 11, 2021 — Pediatric Radiology
Abstract
For two decades, pediatric contrast US has been well accepted throughout Europe and other parts of the world outside the United States because of its high diagnostic efficacy and extremely favorable safety profile. This includes intravenous (IV) administration, contrast-enhanced US (CEUS) and the intravesical application, contrast-enhanced voiding urosonography (ceVUS). However, the breakthrough for pediatric contrast US in the United States did not come until 2016, when the U.S. Food and Drug Administration (FDA) approved the (read more…)

Guideline for ultrasonic diagnosis of liver diseases

Guideline for ultrasonic diagnosis of liver diseases

June 9, 2021 — DocWire News
Abstract
Ultrasound is a non-invasive, real-time, inexpensive, radiation-free and easily repeatable method, usually used for liver imaging. In recent years, new ultrasound examination techniques for liver diseases such as contrast-enhanced ultrasound and elastography have been rapidly developed, which can effectively identify intrahepatic space-occupying lesions, assess the degree of liver fibrosis and portal hypertension, and monitor the effects of treatment. Therefore, these technologies play an important diagnostic role in clinical liver diseases and have therapeutic interventional value. (read more…)

Quantitative analysis of in-vivo microbubble distribution in the human brain

Quantitative analysis of in-vivo microbubble distribution in the human brain

June 3, 2021 — Scientific Reports
Abstract
Microbubbles (MB) are widely used as contrast agents to perform contrast-enhanced ultrasound (CEUS) imaging and as acoustic amplifiers of mechanical bioeffects incited by therapeutic-level ultrasound. The distribution of MBs in the brain is not yet fully understood, thereby limiting intra-operative CEUS guidance or MB-based FUS treatments. In this paper we describe a robust platform for quantification of MB distribution in the human brain, allowing to quantitatively discriminate between tumoral and normal brain tissues and we (read more…)