Global Contrast-Enhanced Ultrasound (CEUS)

Click on any country shaded in orange to see the commercially available agent(s).
 

(Agent(s) commercially available)

 

 

(No agent commercially available at this time)

 

* See package inserts for approved indications. Note that this “Global CEUS” map lists certain ultrasound contrast agents under different product names (i.e., Lumason/SonoVue and Definity/Luminity). ICUS will update this map as additional agents are approved throughout the world.

 

ICUS does not endorse or recommend the use of any ultrasound contrast agent or other medical product. In addition, ICUS does not warrant the accuracy of information provided in package inserts or herein. Medical decisions are the sole responsibility of health care providers and their patients, who are encouraged to carefully evaluate all potential risks and benefits associated with the use of any medical product or procedure including ultrasound contrast agents and (CEUS).


 

Accurate prediction of responses to transarterial chemoembolization for patients with hepatocellular carcinoma by using artificial intelligence in contrast-enhanced ultrasound

Accurate prediction of responses to transarterial chemoembolization for patients with hepatocellular carcinoma by using artificial intelligence in contrast-enhanced ultrasound

January 8, 2020 — European Radiology
Authors: Dan Liu, Fei Liu, Xiaoyan Xie, Liya Su, Ming Liu, Xiaohua Xie, Ming Kuang Guangliang Huang, Yuqi Wang, Hui Zhou, Kun Wang, Manxia Lin, Jie Tian
https://doi.org/10.1007/s00330-019-06553-6
Abstract
Objectives
We aimed to establish and validate an artificial intelligence–based radiomics strategy for predicting personalized responses of hepatocellular carcinoma (HCC) to first transarterial chemoembolization (TACE) session by quantitatively analyzing contrast-enhanced ultrasound (CEUS) cines.
Methods
One hundred and thirty HCC patients (89 for training, 41 for validation), who received ultrasound examination (CEUS (read more…)

Transrectal Subharmonic Ultrasound Imaging for Prostate Cancer Detection

Transrectal Subharmonic Ultrasound Imaging for Prostate Cancer Detection

January 8, 2020 — Uro Today
Authors: I Gupta, B Freid, V Masarapu, P Machado, E Trabulsi, K Wallace, E Halpern, F Forsberg
Thomas Jefferson University, Philadelphia, PA 19107, USA., GE Global Research, Niskayuna NY 12309, USA., Thomas Jefferson University, Philadelphia, PA 19107, USA. Electronic address: flemming.forsberg@jefferson.edu.
http://www.ncbi.nlm.nih.gov/pubmed/31899231
To assess the PCa detection rates of contrast-enhanced, transrectal subharmonic ultrasound imaging (SHI).
This IRB-approved study enrolled 55 subjects. The initial 5 subjects were studied for SHI optimization, while the remaining 50 were evaluated with (read more…)

World’s first cancer treatment being trialed in NHS hospitals could make chemotherapy ‘more effective by using BUBBLES to help kill tumors’

World’s first cancer treatment being trialed in NHS hospitals could make chemotherapy ‘more effective by using BUBBLES to help kill tumors’

Acoustic cluster therapy involves injecting microbubbles and liquid droplets
Ultrasound used to make bubbles grow larger and stretch the tumor’s walls
Increases chance of chemo drugs reaching cancer cells and not healthy ones

Daily Mail (Online) — December 18, 2019
By Connor Boyd, Health Reporter
NHS hospitals are trialling a world-first way of delivering chemotherapy to try and make the grueling cancer treatment more effective. It involves using tiny bubbles to get more drugs inside tumors without damaging healthy cells, a brutal side effect of (read more…)

Contrast-enhanced ultrasound in detecting wall invasion and differentiating bland from tumor thrombus during robot-assisted inferior vena cava thrombectomy for renal cell carcinoma

Contrast-enhanced ultrasound in detecting wall invasion and differentiating bland from tumor thrombus during robot-assisted inferior vena cava thrombectomy for renal cell carcinoma

Uro Today — December 6, 2019
Vena cava thrombus is one of the main clinical manifestations of locally aggressive renal cell carcinoma (RCC). Inferior vena cava (IVC) wall invasion and presence of bland thrombus could affect the surgical outcome. This study aims to assess the value of contrast-enhanced ultrasound (CEUS) in detecting wall invasion and differentiating bland thrombus from tumor thrombus during robot-assisted IVC thrombectomy for RCC.
The intraoperative CEUS findings of 60 patients with RCC accompanied by IVC tumor thrombus were (read more…)

Ultrasound Can Open Blood-Brain Barrier; Treatment could improve drug penetration and toxin removal in Alzheimer’s patients

Ultrasound Can Open Blood-Brain Barrier; Treatment could improve drug penetration and toxin removal in Alzheimer’s patients

December 05, 2019 — MedPage Today
By Ed Susman
In preliminary studies, focused ultrasound directed at the blood-brain barrier briefly made it more porous, which could be a means to allow drugs into Alzheimer’s patients’ brains or permit toxins to escape.
In the phase II safety trial, researchers treated three women diagnosed with Alzheimer’s disease with low-intensity focused ultrasound who had been administered a micro-bubble contrast agent to assess the safety of using the device and treatment.
“The results are promising,” said Rashi Mehta, (read more…)

The Safety and Effectiveness of Intravenous Contrast-Enhanced Sonography in Chinese Children—A Single Center and Prospective Study in China

The Safety and Effectiveness of Intravenous Contrast-Enhanced Sonography in Chinese Children—A Single Center and Prospective Study in China

December 5, 2019 — Frontiers in Pharmacology
Background and Objective:
Intravenous contrast-enhanced ultrasound (CEUS), using the second-generation ultrasound contrast agent SonoVue®, has been widely used in adults. In 2016, it was approved for pediatric applications by the American Food and Drug Administration (FDA). However, it has not been approved by the Chinese Food and Drug Administration (CFDA). The objective of the study was to evaluate the safety and effectiveness of CEUS in children prospectively at a single center in China.
Methods:
A total of (read more…)

Pediatric CEUS Usage Growing Very Fast

Pediatric CEUS Usage Growing Very Fast

Dec 2, 2019 — ICUS
By Kassa Darge, MD
Diagnostic imaging can be a great tool in saving life. However, x-ray, CT and MRI come at a price for children. Radiation, need for sedation or anesthesia and potential serious adverse events of some of the contrast agents are major hurdles to carrying out these studies. No wonder then that there has been such keen interest and remarkable growth in the use of contrast enhanced ultrasound (CEUS), a totally radiation-free, diagnostic imaging modality (read more…)

FDA Approves Ultrasound Enhancing Agent for Use in Pediatric Patients

FDA Approves Ultrasound Enhancing Agent for Use in Pediatric Patients

Dec 2, 2019 — Pharmacy Times
By Aislinn Antrim, Assistant Editor
Officials with the FDA have approved sulfur hexafluoride lipid-type A microspheres for injectable suspension (Lumason, Bracco Diagnostics Inc), for use in echocardiography in pediatric patients. This is the drug’s fourth indication approved by the FDA.
The contrast agent is newly indicated to opacify the left ventricular chamber, and to improve the delineation of the left ventricular endocardial border in pediatric patients with suboptimal echocardiograms. It also is indicated for the same use (read more…)

Can CEUS with second generation contrast agents replace CT angiography for distinguishing between occlusion and pseudo-occlusion of the internal carotid artery?

Can CEUS with second generation contrast agents replace CT angiography for distinguishing between occlusion and pseudo-occlusion of the internal carotid artery?

Clinics (Sao Paulo)
January, 2015
Carlos Augusto Pinto Ventura,I Erasmo Simão da Silva,II Giovanni Guido Cerri,I Pedro Puech Leão,IV Adriano Tachibana,I Maria Cristina ChammasIII
I Hospital das Clı´nicas da Faculdade de Medicina da Universidade de São Paulo, Department of Radiology, São Paulo/SP, Brazil. II Faculdade de Medicina da Universidade de São Paulo, Department of Surgery, São Paulo/SP, Brazil. III Hospital das Clı´nicas da Faculdade de Medicina da Universidade de São Paulo, Department of Ultrasound, São Paulo/SP, Brazil. IV Hospital das Clı´nicas da Faculdade (read more…)

Sound waves and microbubbles to tackle tumours

Sound waves and microbubbles to tackle tumours

The Times — November 13, 2019
By Rhys Blakely, Science Correspondent
Scientists have developed a means of using sound waves to track and manoeuvre tiny parcels of drugs to precise locations inside the body.
The technique could be used to ferry powerfully toxic cancer treatments to tumour sites, avoiding damage to surrounding tissues and dramatically reducing the amount of the drug to which the patient is exposed, researchers said.
It might also be used in gene therapies, where genetic material must reach and infiltrate (read more…)