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January 21, 2021 — Ultrasound in Medicine and Biology


This meta-analysis aimed to evaluate the diagnostic accuracy of contrast-enhanced ultrasonography (CEUS) in identifying lymphazdenopathy. PubMed, Web of Science, Embase and the Cochrane Library were searched for relevant articles through September 2020. A total of 16 articles, which included 1787 participants, were analyzed. The summary sensitivity, specificity, positive likelihood ratio (LR), negative LR and diagnostic odds ratio of CEUS for diagnosing lymphadenopathy were 0.88 (0.86–0.90), 0.90 (0.88–0.92), 6.04 (3.67–9.95), 0.15 (0.10–0.21) and 47.38 (23.45–95.66), respectively. The summary receiver operating characteristic (SROC) area under the curve (AUC) was 0.9405. After omitting outliers identified in a bivariate box plot and forest plot, heterogeneity was decreased, and the pooled sensitivity and specificity were 0.87 (0.84–0.90) and 0.87 (0.84–0.90), respectively. Furthermore, the SROC AUC was 0.9327. In conclusion, CEUS has the potential to be a valuable tool for characterizing lymphadenopathy and could provide clinical decision support.

Authors: Siyang Huang 2; Yunuo Zhao 2;Xian Jiang; Nan Lin; Mingxuan Zhang; Hang Wang; Aiping Zheng; Xuelei Ma

West China School of Medicine, West China Hospital, Sichuan University, Chengdu, China

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