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May 12, 2021 — Pediatric Radiology


Contrast-enhanced ultrasound (CEUS) has emerged as a valuable modality for bowel imaging in adults and children. CEUS enables visualization of the perfusion of the bowel wall and of the associated mesentery in healthy and disease states. In addition, CEUS images can be used to make quantitative measurements of contrast kinetics, allowing for objective assessment of bowel wall enhancement. Bowel CEUS is commonly applied to evaluate inflammatory bowel disease and to monitor treatment response. It has also been applied to evaluate necrotizing enterocolitis, intussusception, appendicitis and epiploic appendagitis, although experience with these applications is more limited. In this review article, we present the current experience using CEUS to evaluate the pediatric bowel with emphasis on inflammatory bowel disease, extrapolating the established experience from adult studies. We also discuss emerging applications of CEUS as an adjunct or problem-solving tool for evaluating bowel perfusion.

Authors: Ami Gokli1, Jonathan R. Dillman2, Paul D. Humphries3, Damjana Ključevšek4, Hans-Joachim Mentzel5, Erika Rubesova6, Marcelo S. Takahashi7, Sudha A. Anupindi1

1 Department of Radiology, Children’s Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, USA
2 Department of Radiology, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, USA
3 University College London Hospital NHS Trust, Great Ormond Street Hospital for Children, London, UK
4 Department of Radiology, University Children’s Hospital Ljubljana, Slovenia
5 Section of Pediatric Radiology, Institute of Diagnostic and Interventional Radiology, University Hospital Jena, Germany
6 Department of Radiology, Lucile Packard Children’s Hospital, Stanford University Medical Center, CA, USA
7 Pediatric Radiology Department, Diagnósticos da America (DASA), São Paulo, Brazil

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