Share on facebook
Share on twitter

November 1, 2018 — European Radiology



To investigate the usefulness of contrast-enhanced ultrasound (CEUS) in the evaluation of renal masses.


This study included 255 patients with renal masses. Ages ranged from 18–86 years. CEUS was used for determining malignancy or benignancy and findings were correlated with the histopathological outcome. Out of 255 lesions, 212 lesions were malignant (83.1%) and 43 were benign (16.9%). Diagnostic accuracy was tested using the histopathological diagnosis as the gold standard.


CEUS showed a sensitivity of 99.1% [95% confidence interval (CI): 96.7%, 99.9%], a specificity of 80.5% (CI: 65.1%, 91.2%), a positive predictive value of 96.4% (CI: 93.0%, 98.4%) and a negative predictive value of 94.3% (CI: 80.8%, 99.3%). Kappa for diagnostic accuracy was κ = 0.85 (CI: 0.75, 0.94). Of 212 malignant lesions, 200 renal cell carcinomas and 12 other malignant lesions were diagnosed. Out of 43 benign lesions, 10 angiomyolipomas, 3 oncocytomas, 8 renal cysts and 22 other benign lesions were diagnosed.


CEUS is an useful method to differentiate between malignant and benignant renal lesions. To date, to our knowledge, this is the largest study in Europe for the evaluation of renal lesions using CEUS with a histopathological validation.

Key Points

• CEUS helps clinicians detect and characterise unclear solid and cystic renal lesions

• CEUS shows a high diagnostic accuracy in the characterization of these lesions

• Proper surgical treatment or follow-up can be given with better diagnostic confidence

Authors: Johannes Rübenthaler, G. Negrão de Figueiredo, K. Mueller-Peltzer, D. A. Clevert

November 2018, Volume 28, Issue 11, pp 4542–4549

Be Part of our Community

ICUS Membership is free.

ICUS Connect