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November 2, 2020 — Ultrasound in Medicine and Biology


The aim of the study was to evaluate and compare contrast-enhanced ultrasound (CEUS)and contrast-enhanced magnetic resonance imaging (CE-MRI) with respect to their valuein the differential diagnosis between benign and malignant mediastinal tumors.

Method:  Forty-two patients with mediastinal tumor underwent CEUS and CE-MRI respectively. The sensitivity, specificity, diagnostic coincidence rate, positive predictive value (PPV) and negative predictive value of the two methods were compared. The value of different enhancement patterns in the differential diagnosis of benign and malignant mediastinal tumorswas analyzed. SonoLiver software was used to obtain the dynamic vascular pattern curve (DVPC) of the lesions, and parameters such as arrival time (AT), rise time (RT), time to peak (TTP), maximum intensity/peak intensity (IMAX) and quality of fit (QOF) were extracted from time–intensity curves for quantitative analysis.

Results:  We found that (i)the specificity of CEUS was higher than that of CE-MRI, and the PPV and diagnostic coincidence rate of CEUS were equal to those of CE-MRI; (ii) the enhancement patterns and DVPC of CEUS differed between the benign and malignant groups, while there was no difference in CE-MRI enhancement intensity; and (iii) AT, RT and TTP in the malignant groups were significantly shorter, while IMAX was significantly higher.

Conclusions:  The application of quantitative parameters and DVPC of CEUS is worth popularizing. CEUS can be used as an effective alternative and complementary examination for patients who cannot undergo CE-MRI.

Authors – Juhong Pan; Wenwei Chen; Haidong Zhang; Xingyue Huang; Xin Huang

Department of Ultrasound, Renmin Hospital of Wuhan University, Wuhan, China


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