ICUS Weekly News Monitor 8-18-2016

1.  Dove Medical Press,  Aug 12,2016,  Diagnosis of prostate cancer using anti-PSMA aptamer A10-3.2-oriented lipid nanobubbles      Authors:  Xiaozhou Fan, et al
 
2.  Science Daily,  Aug 9, 2016,  Researchers immobilize underwater bubbles
Source: American Institute of Physics, Authors: Zoubida Hammadi, et al
 
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Dove Medical Press
Volume 2016:11 Pages 3939—3950
DOI https://dx.doi.org/10.2147/IJN.S112951
Aug 12,2016
 
Diagnosis of prostate cancer using anti-PSMA aptamer A10-3.2-oriented lipid nanobubbles
 
Authors:  Xiaozhou Fan,1 Yanli Guo,1 Luofu Wang,2 Xingyu Xiong,1 Lianhua Zhu,1 Kejing Fang1
1Department of Ultrasound, Southwest Hospital, Third Military Medical University, Chongqing, People’s Republic of China; 2Department of Urology, Daping Hospital, Institute of Surgery Research, Third Military Medical University, Chongqing, People’s Republic of China
 
Abstract:
In this study, the lipid targeted nanobubble carrying the A10-3.2 aptamer against prostate specific membrane antigen was fabricated, and its effect in the ultrasound imaging of prostate cancer was investigated. Materials including 2-dipalmitoyl-sn-glycero-3-phosphocholine, 1,2-dipalmitoyl-sn-glycero-3-phosphatidic acid, 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine, 1,2-dipalmitoyl-sn-glycero-3-phosphoglycerol, carboxyl-modified 1,2-distearoyl-sn-glycero-3-phosphoethanolamine, and polyethyleneglycol-2000 were for mechanical oscillation, and nanobubbles were obtained through the centrifugal flotation method. After mice were injected with nanobubbles, abdominal color Doppler blood flow imaging significantly improved. Through left ventricular perfusion with normal saline to empty the circulating nanobubbles, nanobubbles still existed in tumor tissue sections, which demonstrated that nanobubbles could enter tissue spaces via the permeability and retention effect. Fluorinated A10-3.2 aptamers obtained by chemical synthesis had good specificity for PSMA-positive cells, and were linked with carboxyl-modified 1,2-distearoyl-sn-glycero-3-phosphoethanolamine lipid molecules from the outer shell of nanobubbles via amide reaction to construct targeted nanobubbles. Gel electrophoresis and immunofluorescence confirmed that targeted nanobubbles were fabricated successfully. Next, targeted nanobubbles could bind with PSMA-positive cells (C4-2 cells), while not with PSMA-negative cells (PC-3 cells), using in vitro binding experiments and flow cytometry at the cellular level. Finally, C4-2 and PC-3 xenografts in mice were used to observe changes in parameters of targeted and non-targeted nanobubbles in the contrast-enhanced ultrasound mode, and the distribution of Cy5.5-labeled targeted nanobubbles in fluorescent imaging of live small animals. Comparison of ultrasound indicators between targeted and non-targeted nanobubbles in C4-2 xenografts showed that they had similar peak times (P>0.05), while the peak intensity, half time of peak intensity, and area under the curve of ½ peak intensity were significantly different (P<0.05). In PC-3 xenografts, there were no differences in these four indicators. Fluorescent imaging indicated that targeted nanobubbles had an aggregation ability in C4-2 xenograft tumors. In conclusion, targeted nanobubbles carrying the anti-PSMA A10-3.2 aptamer have a targeted imaging effect in prostate cancer.
 
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Science Daily
Aug 9, 2016
 
Researchers immobilize underwater bubbles
New technique to 'freeze' newly created microbubbles in their tracks could lead to new applications in medicine and the nuclear industry
 
Source: American Institute of Physics
Authors: Zoubida Hammadi, Laurent Lapena, Roger Morin, Juan Olives.
Immobilization of a bubble in water by nanoelectrolysis;  Applied Physics Letters, 2016; 109 (6): 064101 DOI: 10.1063/1.4960098
 
Controlling bubbles is a difficult process and one that many of us experienced in a simplistic form as young children wielding a bubble wand, trying to create bigger bubbles without popping them. A research team in CINaM-CNRS Aix-Marseille Université in France has turned child's play into serious business.
 
They demonstrated they could immobilize a microbubble created from water electrolysis as if the Archimedes' buoyant force that would normally push it to the surface didn't exist. This new and surprising phenomenon described this week in Applied Physics Letters, from AIP Publishing, could lead to applications in medicine, the nuclear industry or micromanipulation technology.
 
While bubbles are observed frequently in nature, it is not easy to control their diameter, position or time of formation. Previous work by the French research team explored how to control the hydrogen and oxygen gas bubbles formed by the breakdown of water using electricity. They showed that if one of the electrodes is tip-shaped -- with a curvature radius at its apex ranging from 1 nanometer to 1 micrometer -- and an alternating electric current with defnite values of amplitude and frequency was used, microbubbles could be produced at a single point at the apex of the nanoelectrode.
 
In the current work, the team has demonstrated a new and surprising phenomenon: the immobilization of a single microbubble in water. After a bubble is produced (at the apex of the nanoelectrode), it is immobilized by rapidly increasing the frequency of the electric current. It is a stable situation: No matter which direction the electrode moves, the bubble remains above and at the same distance from the electrode.
 
The scientists propose that the hydrogen or oxygen molecules enter the immobilized bubble through the lower surface and exit the bubble through the upper surface. The gas molecules are only produced at a single point at the apex of the nanoelectrode.
 
The team from CINaM-CNRS worked with researchers in acoustics who use ultrasounds for the detection and the characterization of microbubbles. They needed highly calibrated bubbles and the team proposed producing such bubbles using water electrolysis. The team incorporated a number of new ideas and methods in their approach. "While it is usual to consider that electrolysis is controlled by the electric potential, we show that the fundamental quantity is in fact the electric field which is why we use a tip-shaped electrode with a very small curvature radius at the apex," said Juan Olives, a member of the research team. The use of an alternating current of sufficient frequency then produces "nanoelectrolysis," which is the nanolocalization of the electrolysis reactions at a single point.
 
The greatest surprise in the findings was that, although nothing seems to move when you observe the experiment, in fact, all is moving in an apparent steady state, Olives said. Hydrogen and oxygen molecules are continually produced at the apex of the nanoelectrode, they move in the solution and in the bubble, they enter and leave the bubble, and there is a convection velocity in the solution and in the bubble. Everything is moving, except the surface of the bubble, Olives said.
 
Controlling microbubbles is critical to numerous applications in medicine including as ultrasound contrast agents, for breaking up blood clots, and for gas embolotherapy, which is the intentional blocking of an artery to prevent excessive blood loss. Controlling microbubbles is also important in the nuclear industry, where microbubbles in liquid sodium coolant can cause problems.

ICUS Weekly News Monitor 8-4-2016

1. Journal of Controlled Release,  Aug 28, 2016,  Acoustic Cluster Therapy (ACT) enhances the therapeutic efficacy of paclitaxel and Abraxane® for treatment of human prostate adenocarcinoma in mice       Authors:  Annemieke van Wamel, et al
 
2.  UMR Inserm U930,  Jun 30, 2016,  A New Dawn for Sonoporation with Creation of a Proof-of-Concept Consortium           Media release
 
_________________________________________________________________
Journal of Controlled Release
Volume 236, doi:10.1016/j.jconrel.2016.06.018
Aug 28, 2016,
 
Acoustic Cluster Therapy (ACT) enhances the therapeutic efficacy of paclitaxel and Abraxane® for treatment of human prostate adenocarcinoma in mice
 
Authors:  Annemieke van Wamela, Per Christian Sontumb, Andrew Healeyb, Svein Kvåleb, Nigel Bushc, Jeffrey Bamberc, Catharina de Lange Daviesa
a Dept. of Physics, NTNU, Norwegian University of Science and Technology, Trondheim, Norway
b Phoenix Solutions AS, Oslo, Norway
c Joint Dept. of Physics, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, UK
 
Abstract
Acoustic cluster therapy (ACT) is a novel approach for ultrasound mediated, targeted drug delivery. In the current study, we have investigated ACT in combination with paclitaxel and Abraxane® for treatment of a subcutaneous human prostate adenocarcinoma (PC3) in mice. In combination with paclitaxel (12 mg/kg given i.p.), ACT induced a strong increase in therapeutic efficacy; 120 days after study start, 42% of the animals were in stable, complete remission vs. 0% for the paclitaxel only group and the median survival was increased by 86%. In combination with Abraxane® (12 mg paclitaxel/kg given i.v.), ACT induced a strong increase in the therapeutic efficacy; 60 days after study start 100% of the animals were in stable, remission vs. 0% for the Abraxane® only group, 120 days after study start 67% of the animals were in stable, complete remission vs. 0% for the Abraxane® only group. For the ACT + Abraxane group 100% of the animals were alive after 120 days vs. 0% for the Abraxane® only group. Proof of concept for Acoustic Cluster Therapy has been demonstrated; ACT markedly increases the therapeutic efficacy of both paclitaxel and Abraxane® for treatment of human prostate adenocarcinoma in mice.
 
Graphical abstract
 
image007-1
 
 
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UMR Inserm U930
Jun 30, 2016
 
A New Dawn for Sonoporation with Creation of a Proof-of-Concept Consortium
Media release
 
TOURS, France - The Imaging and Ultrasound Team of the Imaging and Brain Inserm Unit U930 in Tours France, working in collaboration with colleagues at the Erasmus University Medical Center in Rotterdam, the Academic Medical Center in Amsterdam, the University Medical Center in Utrecht, (all 3 in the Netherlands), the University of Washington, Seattle USA and Advice-US Consulting, a Swiss Ultrasound Consultancy firm; have today launched a proof-of-concept research Consortium to evaluate the safety, tolerability and efficacy of sonoporation. This is a drug-delivery system based on the use of ultrasound and microbubbles in combination with oncolytic therapeutics to treat a range of tumour types in late-stage cancer patients. The Consortium tasked with the singular goal of translating sonoporation to the clinic is funded by a small pump-priming grant from LE STUDIUM® Loire Valley Institute of Advanced Studies, and brings together a multidisciplinary cohort of scientist, engineers and clinical practitioners (Prof Mike Averkiou, Dr Ayache Bouakaz, Dr Jean-Michel Escoffre Prof Nico de Jong, Dr Klazina Kooiman, Prof Heneke van Laarhoven, Prof Chrit Moonen, Dr Anthony Novell, Dr Charles A Sennoga and Prof Francois Tranquart). The Consortium’s scientific programme is led by Dr Ayache Bouakaz and coordinated by Dr Charles A Sennoga (both of Inserm U930). It is anticipated that the protocols developed, if clinically implemented will not only add a new cancer treatment to the clinical oncology toolbox but also go some way to filling existing gaps in our cancer management knowledge.
 
About Sonoporation:
It has long been recognized that ultrasound waves can facilitate the delivery of both large particles and therapeutic macromolecules into cells and other biological tissues by creating transient nonlethal perforations. Although this requires high acoustic power, well beyond that permitted for medical imaging, the power needed can be greatly reduced when microbubbles are used as an adjunct. This is because microbubbles lower the amount of energy necessary for cavitation, a process in which extreme oscillations induced by ultrasound pulses lead to microbubble collapse. As a result, cavitation of microbubbles in capillary beds increases capillary permeability, which improves local access of the released therapeutic agent. While the potential of sonoporation has already been harnessed as a drug-delivery tool in a wide range of pre-clinical studies, its application in humans is currently limited to a handful of publications. Guided by ultrasound images, researchers can now harness microbubble and ultrasound not only to home in on specific tumours and deliver drugs at precise targets but also monitor treatment response. For more information about sonoporation and the newly launched Sonoporation Consortium, please visit http://www.lestudium-ias.com/consortium/sonoporation-therapy-vitro-vivo-patients
 
About Imaging and Brain UMR Inserm U930
Founded in 2004, Inserm U930 seeks to empower this generation of creative scientists to transform medicine. The Inserm "Imaging and Brain" Research Unit U930 at Université François-Rabelais de Tours is interested in normal and pathological brain development, from the perinatal period to adulthood. The main focus of Inserm U930 is to develop, validate and clinically implement, new functional and structural brain imaging methods (MRI, PET, SPECT, EEG, ultrasound) in order to better characterize brain functioning and development; and to better understand brain pathological conditions. Inserm U930 seeks to develop effective new approaches for diagnostics and therapeutics; and disseminate discoveries, tools, methods and data openly to the entire scientific community. Inserm U930 includes faculty, professional staff and students from throughout the Faculty of Medicine, the biomedical research communities of the Université Francois-Rabelais and beyond, with additional collaborations spanning over several private and public institutions in many countries worldwide. For further information about the UMR Inserm U930, please visit http://www.u930.tours.inserm.fr/home

ICUS Weekly News Monitor 7-15-2016

1.  Ultraschall in Med 2016,  Jul 1, 2016,  Role of Contrast-Enhanced Ultrasound (CEUS) in Paediatric Practice: An EFSUMB Position Statement       Authors P. S. Sidhu, et al
 
2.  The Oregonian,  Jun 26, 2016,  OHSU-led study could help NASA's mission to Mars
By Lynne Terry
 
3.  National Space Biomedical Research Institute (NSBRI),  May 21, 2015,  NASA, NSBRI Select 24 Proposals to Support Crew Health of Astronauts on Deep Space Missions      Media Release
 
______________________________________
Ultraschall in Med 2016
DOI http://dx.doi.org/10.1055/s-0042-110394
Published online: 2016 Ultraschall in Med © Georg
Thieme Verlag KG Stuttgart ·New York · ISSN 0172-4614
Jul 1, 2016
 
Role of Contrast-Enhanced Ultrasound (CEUS) in Paediatric Practice: An EFSUMB Position Statement
Authors:   P. S. Sidhu1, V. Cantisani2, A. Deganello1, C. F. Dietrich3, C. Duran4, D. Franke5, Z. Harkanyi6,W. Kosiak7, V. Miele8, A. Ntoulia1, M. Piskunowicz9, M. E. Sellars1, O. H. Gilja10
 
Correspondence
Dr. Paul S. Sidhu
Radiology, King's College London, King's College Hospital
Denmark Hill, SE5 9RS London, UK
Tel.: ++ /44/2 03/2 99 41 64;  Fax: ++ 44/2 03/29 91 57
This email address is being protected from spambots. You need JavaScript enabled to view it.
 
Abstract
The use of contrast-enhanced ultrasound (CEUS) in adults is well established in many different areas, with a number of current applications deemed “off-label”, but the use supported by clinical experience and evidence. Paediatric CEUS is also an “off-label” application until recently with approval specifically for assessment of focal liver lesions. Nevertheless there is mounting evidence of the usefulness of CEUS in children in many areas, primarily as an imaging technique that reduces exposure to radiation, iodinated contrast medium and the “patient-friendly” circumstances of ultrasonography. This position statement of the European Federation of Societies in Ultrasound and Medicine (EFSUMB) assesses the current status of CEUS applications in children and makes suggestions for further development of this technique.
 
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The Oregonian
Jun 26, 2016
 
OHSU-led study could help NASA's mission to Mars
By Lynne Terry
 
image007
 
Dr. Jonathan Lindner is head of imaging at the Knight Cardiovascular Institute at Oregon Health & Science University. For two decades, he's been looking for ways to identify the susceptibility for cardiovascular disease, in hopes of treating it at its inception.
 
Oregon cardiologists have hooked up with NASA to find better ways to screen astronauts who will take the next giant leap into space.
 
The National Aeronautics and Space Administration plans to send astronauts to an asteroid by 2025 and to Mars in the 2030s. But those missions will carry physical risks. In deep space, astronauts face being blasted with cosmic and solar radiation, threatening their cardiovascular systems.
 
The Oregon team, led by a cardiologist at Oregon Health & Science University, can't control the cosmos. But armed with a grant of nearly $1 million from the National Space Biomedical Research Institute, which works with NASA, they hope to uncover new ways to diagnose cardiovascular problems at an early stage to help astronauts and the rest of us.
 
"I will guarantee one thing and that is that this process is going to teach us a tremendous amount about how to treat people on Earth," said Dr. Jonathan Lindner, an OHSU cardiologist and lead investigator on the study. "To me, that's the big impact of this project."
 
Lindner's driving goal – one he's been pursuing for two decades – is to be able to thwart cardiovascular disease by identifying the disease early, when it's the most treatable. Right now, physicians are forced to scramble after symptoms, trying to slow progression of the disease and stem complications.
 
"There's not a cardiologist out there who has ever cured coronary disease," Lindner said. "We bypass it. We smush it. We stent it. We palliate it with medications. But nobody has ever cured anything."
 
Cardiologists know from studying the effects of radiation on Earth – from atomic bombs, radiation therapy and nuclear accidents – that it hurts the heart in multiple ways. It damages the muscle so it doesn't beat as well. It hurts the connective tissue, which becomes stiff. And it harms the lining of the blood vessels, which plays a key role in the build-up of plaque.
 
Atherosclerosis – the hardening of the arteries – can cause heart attacks, strokes and vascular disease.
 
While man-made radiation poses a risk on Earth, blasts from the sun do not. The planet's magnetic force defects them. But once astronauts leave low Earth orbit – where the International Space Station lives – they're bombarded by solar and cosmic radiation.
 
NASA can't build spacecraft to protect astronauts from all that radiation, Lindner said. The shielding would make the vessels too unwieldy.
 
And the threat from radiation can last a lifetime.
 
"The risk is not just around the time of being radiated," Lindner said. "It's lifelong."
 
His lab – and researchers at Oregon State University – will use advanced techniques to try to identify markers of cardiovascular disease beyond what's available now to use in the space program.
 
NASA chooses the fittest candidates who are in outstanding health. But they're picked long before they fly. As the years pass, their health changes, just like the rest of us.
 
"The reality is that cardiovascular disease is still a significant risk for any human being who's in their 40s, 50s or 60s," said Graham Scott, vice president and chief scientist of the National Space Biomedical Research Institute, which is partnered with NASA. "We would like to be able to detect at the earliest time possible if the cardiovascular status an astronaut is changing."
 
The idea would be to intervene early, with a drug, exercise regime or something else, to counteract that change.
 
Any new diagnostics that pass the necessary validation hurdles could even be used while astronauts are in flight or during the selection process.
 
The study will last two years and include 60 people between 35 and 55 who've undergone an advanced CT scan of the coronary blood vessels. Some might have a little plaque build-up. Others will have clear vessels. But no one admitted to the study will have severe blockage because those people would be excluded from the astronaut program.
 
Participants will undergo further testing. Researchers will use advanced imaging techniques developed at OHSU to check the health of their blood vessel linings. The endothelium, as its called, determines the susceptibility to developing plaque. It plays a key role in controlling inflammation and in the formation of blood clots.
 
Endothelial dysfunction is a harbinger of cardiovascular disease.
 
The final round of testing will involve blood tests. Scientists at OHSU and Oregon State University will analyze each person's blood, looking at their metabolism, genetics and the way their bodies handle lipids. These tests will reveal the "fingerprints" of how each person responds to their environment and offer clues about their susceptibility to disease.
 
Scientists will compare the tests, looking for connections. Any findings could lead to a new cardiovascular diagnostic test.
 
New tools will help NASA as it prepares to send men and women to Mars.
 
"Who are the people who are the most susceptible to atherosclerotic disease? That may help us determine candidacy for the astronaut program to Mars and for other deep space missions," Lindner said.
 
It could also help cardiologists – and patients -- here on Earth.
 
Once scientists figure out how heart disease starts, whether it's in response to radiation, a poor diet or inactivity, they'll have a key to preventing its progression and maybe even finding a cure.
 
___________________________________________
National Space Biomedical Research Institute (NSBRI)
May 21, 2015
 
NASA, NSBRI Select 24 Proposals to Support Crew Health of Astronauts on Deep Space Missions
Media Release
 
NASA’s Human Research Program (HRP) and the National Space Biomedical Research Institute (NSBRI) will fund 24 proposals to help investigate questions about astronaut health and performance on future deep space exploration missions. The selected proposals will investigate the impact of the space environment on various aspects of astronaut health, including visual impairment, behavioral health, bone loss, cardiovascular alterations, human factors and performance, neurobehavioral and psychosocial factors, sensorimotor adaptation and the development and application of smart medical systems and technologies. All of the selected projects will contribute towards NASA’s future missions to Mars.
 
The selected studies represent how HRP and NSBRI work together to address the practical problems of spaceflight that impact astronaut health. HRP and NSBRI research provides knowledge and technologies that may improve human health and performance during space exploration. They also develop potential countermeasures for problems experienced during space travel. The organizations’ goals are to help astronauts complete their challenging missions successfully and preserve their long-term health. This applied research will be conducted in laboratory settings as well as ground-analog settings that mimic the spaceflight environment. Selected studies include one by Dr. Gary Strangman, Associate Professor at Massachusetts General Hospital in Boston, who will design, develop, and test a near infrared spectroscopy-electroencephalography system for sleep research in a realistic spaceflight analog environment. Dr. Valerie Meyers, a toxicologist at NASA’s Johnson Space Center in Houston, will examine the effects of carbon dioxide on cognitive performance in high-level decision-making in astronaut-like populations. Dr. Benjamin Levine, Professor in Internal Medicine at the University of Texas Southwestern Medical Center in Dallas, will assess the risk of atrial fibrillation in crewmembers participating in long-duration spaceflight missions.
 
The selected proposals are from 21 institutions in 11 states and will receive a total of about $12.9 million during a one- to three-year period. The 24 projects were selected from 178 proposals received in response to the research announcement entitled, “Research and Technology Development to Support Crew Health and Performance in Space Exploration Missions.” Science and technology experts from academia and government reviewed the proposals. NASA will manage 17 of the projects and NSBRI will manage seven. Six of the investigators are new to HRP and NSBRI.
 
HRP quantifies crew health and performance risks during spaceflight and develops strategies that mission planners and system developers can use to monitor and mitigate the risks. These studies often lead to advancements in understanding and treating illnesses in patients on Earth.
 
NSBRI is a NASA-funded consortium of institutions studying health risks related to long-duration spaceflight. The Institute’s science, technology and career development projects take place at approximately 60 institutions across the United States.
 
Listed below is the complete list of the selected proposals, principal investigators and organizations:
 
NASA Awards
•             Dr. Dorrit Billman, San Jose State University Research Foundation, “Training for Generalizable Skills & Knowledge: Integrating Principles and Procedures”
•             Dr. Kim Binsted, University of Hawaii, “Using Analog Missions to Develop Effective Team Composition Strategies for Long Duration Space Exploration”
•             Dr. Mary Bouxsein, Beth Israel Deaconess Medical Center, “Vertebral Strength and Fracture Risk Following Long Duration Spaceflight”
•             Ms. Toni Clark, NASA Johnson Space Center, “Computational Modeling to Limit the Impact Displays and Indicator Lights Have on Habitable Volume Operational Lighting Constraints”
•             Dr. Noshir Contractor, Northwestern University, “CREWS: Crew Recommender for Effective Work in Space”
•             Prof. Leslie DeChurch, Georgia Institute of Technology, “SCALE: Shared Cognitive Architectures for Long-term Exploration”
•             Dr. Douglas Ebert, Wyle Laboratories, “Evaluation of an Impedance Threshold Device as a VIIP Countermeasure”
•             Dr. Edward Foegeding, North Carolina State University, “High-Protein And Polyphenol Bar Formulations: Utilizing Whey Protein-Polyphenol Ingredients”
•             Dr. Adam Gonzalez, State University Of New York, Stony Brook, “Asynchronous Techniques for the Delivery of Empirically Supported Psychotherapies”
•             Dr. Kritina Holden, Lockheed Martin, “Electronic Procedures for Crewed Missions Beyond Low Earth Orbit (LEO)”
•             Dr. Benjamin Levine, University of Texas Southwestern Medical Center at Dallas, “Integrated Cardiovascular (ICV) 2.0: Assessing the Risk for Atrial Fibrillation in Astronauts During Long Duration Spaceflight”
•             Dr. Steven Lockley, Brigham and Women’s Hospital, Harvard Medical School, “Lighting Protocols for Exploration – HERA Campaign”
•             Dr. Valerie Meyers, NASA Johnson Space Center, “Effects of Acute Exposures to Carbon Dioxide upon Cognitive Functions”
•             Dr. Greg Perlman, State University of New York, Stony Brook, “Personality and Biological Predictors of Resiliency to Chronic Stress among High-Achieving Adults”
•             Dr. Raphael Rose, University of California, Los Angeles, “Asynchronous Behavioral Health Treatment Techniques”
•             Dr. Jeffrey Ryder, Universities Space Research Association, “Sweat Rates During Continuous and Interval Aerobic Exercise: Implications for NASA Multipurpose Crew Vehicle (MPCV) Missions”
•             Dr. Richard Simpson, University of Houston, “The Impact of Modeled Microgravity and Prior Radiation Exposure on Cytomegalovirus Reactivation and Host Immune Evasion”
NSBRI Awards
•             Dr. Henry Donahue, Pennsylvania State University, “Somatic Mutations in Muscle and Bone Exposed to Simulated Space Radiation and Microgravity”
•             Dr. Robert Hienz, Johns Hopkins University, “Countermeasures for Neurobehavioral Vulnerabilities to Space Radiation”
•             Dr. Jonathan Lindner, Oregon Health & Science University, “Biomarker Assessment for Identifying Heightened Risk for Cardiovascular Complications During Long-duration Space Missions”
•             Dr. Brandon Macias, University Of California, San Diego, “Validation of a Cephalad Fluid Shift Countermeasure”
•             Ms. Debra Schreckenghost, TRACLabs, “Quantifying and Developing Countermeasures for the Effect of Fatigue-Related Stressors on Automation Use and Trust during Robotic Supervisory Control”
•             Dr. Gary Strangman, Massachusetts General Hospital, Harvard Medical School, “Sleep Electroencephalography and Near-Infrared Spectroscopy Measurements for Spaceflight and Analogs”
•             Dr. Gary Strangman, Massachusetts General Hospital, Harvard Medical School, “Testing Mechanical Countermeasures for Cephalad Fluid Shifts”
 
NSBRI Contact:
Graham B.I. Scott, Ph.D.
Vice President, Chief Scientist, & Institute Associate Director
National Space Biomedical Research Institute, (NSBRI)
 
This email address is being protected from spambots. You need JavaScript enabled to view it.
Tel: (713) 798-7227

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