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Aug 9, 2020 — Ultrasound in Medicine and Biology


The capability of contrast‐enhanced ultrasound (CEUS) to assess the prognosis and chronicity of chronic kidney disease (CKD) was evaluated in patients diagnosed with CKD in 2014 at Ren Ji Hospital, Shanghai, China. Time–intensity curves and quantitative indexes were created using QLab quantification software. Kidney biopsies were analyzed with α-smooth muscle actin immunohistochemistry. According to the renal chronicityscore, patients were divided into four groups: minimal (n = 14), mild (n = 73), moderate(n = 49) and severe (n = 31). Multivariate logistic regression analysis revealed that the derived peak intensity (DPI) was independently associated with the renal chronicity score. Of 167 CKD patients (median follow-up: 30.4 ± 18.7 mo), 31 (18.6%) exhibited CKD progression, with a decline in the glomerular filtration rate of more than 25% or end-stage renal disease. Multivariate Cox regression analysis revealed that a lower DPI was independently associated with CKD progression. This study indicates that DPI is a reliable CEUS parameter for evaluating chronic renal changes and an independent prognostic factor of CKD.

Authors: Yao Xu; Hongli Li; Chunlin Wang; Minfang Zhang; Qin Wang; Yuanyuan Xie; Xinghua Shao; Lei Tian; Yanhong Yuan; Wei Yan; Tienan Feng; Fenghua Li; Zhaohui Ni; Shan Mou

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