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Comparative Effectiveness of CEUS
Cardiovascular
- For diagnosis of coronary artery disease, stress echocardiography with contrast is more accurate than stress echocardiography without contrast, and seems comparable to the accuracy of 99 technetium SPECT.
- The accuracy of CEUS in detecting endoleaks after EVAR is markedly better than CDUS and is similar to CTA and MRA. CEUS seems to be a feasible tool in the long-term surveillance after EVAR, and it may better classify endoleaks missed by other imaging techniques.
Body Imaging
- CEUS leads to a significant improvement in the detection of liver lesions. For patients after adjuvant chemotherapy as well as for cases of small nodular metastases a CEUS should be carried out as a routine.
- Compared with dynamic CT, CEUS was superior at characterizing specific dynamic features. Considering that it is radiation-free, readily availability and easy to use, CEUS is suggested as the first line imaging tool to diagnose hepatocellular adenoma (HCA).
- CEUS, an equivalent to CEMRI, may have an added diagnostic value in hemangiomas.
- In the detection of HCC tumor vascularity and assessment of response to thermal ablation after 1 month, real time CEUS provided results comparable to those obtained with CECT/CEMRI. CEUS proved to be a safe and easy to access procedure, with potential for diagnostic impact in the clinical practice.
- CEUS was found to be better than unenhanced sonography and CT in the diagnosis of malignancy in complex cystic renal masses.
- CEUS and SCT provide a similar diagnostic accuracy in the characterization of focal liver lesions, with a good degree of correlation between the two techniques.
- The accuracy of CEUS is comparable to that of MRE (Magnetic Resonance Enterography) in the assessment of active, uncomplicated terminal ileal Crohn’s disease and therefore a valuable bedside alternative to MRE in the follow-up of these patients.
- CEUS had significantly higher diagnostic efficacy than baseline ultrasound in patients with renal pelvis lesions.
- Enhanced US and MR provided clear images and accurate information during follow-up of prostatic radiofrequency ablation. However, CEUS has the advantage of being more economical, using more convenient equipment and faster scanning, thus identifying it as the more feasible choice. Furthermore, no notable advantages were observed among any image examinations in the long term follow‑up.
Pediatric
- Darge K (2008) Voiding urosonography with US contrast agents for the diagnosis of vesicoureteric reflux in children. II. Comparison with radiological examinations. Pediatr Radiol 38:54–63
- Farina R, Pennisi F, La Rosa M et al (2008) Contrast-enhanced colour-Doppler sonography versus pH-metry in the diagnosis of gastrooesophageal reflux in children. Radiol Med 113:591–598
