ICUS Weekly News Monitor 1-6-2017

ICUS Weekly News Monitor
6 January, 2017 - 9am Eastern
1.  American Journal of Roentgenology,  Feb 1, 2017,  Retrospective Analysis of the Safety and Cost Implications of Pediatric Contrast-Enhanced Ultrasound at a Single Center    Authors:  Gibran T. Yusuf, et al
2.,  Jan 3, 2017,  Micro-Ultrasound in Cancer Research     By Susha Cheriyedath, MSc
3.  EFSUMB,  Educational Webinars Related to Ultrasound:  19 Jan  2017, 18:00 CET  --  CEUS LI RADS:  The New Classification of Focal Liver Lesions at Risk for HCC

American Journal of Roentgenology
Feb 1, 2017
Retrospective Analysis of the Safety and Cost Implications of Pediatric Contrast-Enhanced Ultrasound at a Single Center
Authors:  Gibran T. Yusuf1; Maria E. Sellars; Annamaria Deganello; David O. Cosgrove; Paul S. Sidhu
1All authors: Department of Radiology, King’s College
London, King’s College Hospital, Denmark Hill, London
SE5 9RS, UK. Address correspondence to G. T. Yusuf
( This email address is being protected from spambots. You need JavaScript enabled to view it. ).
OBJECTIVE. Because of concern over medical ionizing radiation exposure of children,
contrast-enhanced ultrasound (CEUS) has generated interest as an inexpensive, ionizing radiation–free alternative to CT and MRI. CEUS has received approval for pediatric hepatic use
but remains off-label for a range of other applications. The purposes of this study were to retrospectively analyze adverse incidents encountered in pediatric CEUS and to assess the financial benefits of reducing the number of CT and MRI examinations performed.
MATERIALS AND METHODS. All pediatric (patients 18 years and younger) CEUS
examinations performed between January 2008 and December 2015 were reviewed. All immediate
reactions deemed due to contrast examinations were documented in radiology reports.
Electronic patient records were examined for adverse reactions within 24 hours not due
to an underlying pathologic condition. With tariffs from the U.K. National Institute of Clinical
Excellence analysis, CEUS utilization cost ($94) was compared with the CT ($168) and
MRI ($274) costs of the conventional imaging pathway.
RESULTS. The records of 305 pediatric patients (187 boys, 118 girls; age range, 1
month–18 years) undergoing CEUS were reviewed. Most of the studies were for characterizing
liver lesions (147/305 [48.2%]) and trauma (113/305 [37.1%]); the others were for renal,
vascular, and intracavitary assessment (45/305 [14.8%]). No immediate adverse reactions occurred.
Delayed adverse reactions occurred in two patients (2/305 [0.7%]). These reactions
were transient hypertension and transient tachycardia. Neither was symptomatic, and both
were deemed not due to the underlying disorder. The potential cost savings of CEUS were $74
per examination over CT and $180 over MRI.
CONCLUSION. Pediatric CEUS is a safe and potentially cost-effective imaging modality.
Using it allows reduction in the ionizing radiation associated with CT and in the gadolinium
Jan 3, 2017
Micro-Ultrasound in Cancer Research
By Susha Cheriyedath, MSc
Cancer angiogenesis is a key focal point in biomedical research. However, lack of a high resolution and portable imaging technique that helps in non-invasive, real-time quantification of various parameters is a huge challenge facing cancer research studies in animals.
In cancer research, scientists need to visualize the tumor in real time, to study the effects of drugs on the tumor and aid in further drug discovery. In order to achieve this, they need imaging techniques that help them visualize tumor angiogenesis in a non-invasive manner in real time. Traditional methods including dissection and histology are not of much help in this regard. This is where micro-ultrasound tool is of great use to researchers.
Micro-ultrasound uses intravenous contrast agents and very high frequency probes to image tissues in fine detail. It is a promising technique for studying angiogenesis and monitoring therapy. Angiogenesis research is usually performed on mice, as they are easily available in many strains and are also easy to handle. Micro-ultrasound is particularly useful in this application due to the small size of the mice.
Why micro-ultrasound?
Several cancer research groups have used micro-ultrasound successfully in angiogenesis visualization. They reported the advantages of using micro-ultrasound as compared to conventional imaging tools such as CT, MRI, SPECT, and PET.
These systems have significant drawbacks including complicated operating requirements. None of them provide real-time visualization like micro-ultrasound, which can provide images at 300 frames per second, which helps analyze blood flow and perfusion. A study by Loveless et al showed that micro-ultrasound can be combined with MRI in order to validate results from both the tools.
Micro-ultrasound using contrast agents
Contrast agents used in micro-ultrasound improves imaging. These are materials which have optical or acoustic properties that are different from those of the target tissues, and are injected into the bloodstream.
Mechanism of drug action
New tools have emerged in the past decade for the targeted treatment of patients with metastatic lung, breast and renal cancer. However, understanding the mechanism of action of these drugs and identifying the category of patients that they benefit the most has been a challenge.
Also, there is a lack of biomarkers that can be used to track response to therapy as well as resistance to treatment. Micro-ultrasound is ideal for studying these aspects in preclinical models.
Tumor volume and changes
Micro-ultrasound provides a non-invasive way of repeatedly monitoring changes in a tumor over a long period of time. The same animal can be monitored, and acts as its own control. This boosts the accuracy of the study and reduces the number of animals required.
Using micro-ultrasound, tumors can be continuously monitored and measured right from initiation of therapy, through different stages of their growth, and during metastases to other organs, tissues and lymph nodes.
It has been shown by several studies that the use of micro-ultrasound enables accurate monitoring of tumor size. Images from 3D micro-ultrasound closely correlated with histology images and also precisely confirmed the tumor size and shape in vivo.
Other studies reported that 3D micro-ultrasound can not only be used for non-invasive monitoring of tumor volume and growth, but also for evaluating possible chemotherapeutic agents in murine cancer models.
Micro-ultrasound systems from Vevo and VisualSonics
A novel micro-ultrasound system developed by VisualSonics seems to be a promising solution to this problem. The revolutionary new technique allows collection of a large amount of data over the entire lifespan of the animals studied, thus reducing the number of animals required. The new system helps rapidly quantify tumor vascularity, 3D tumor volume, and tissue perfusion.
Vevo MicroMarker® contrast agents help in visualizing capillaries and monitoring the expression of VEGF and other such endothelial cell markers. Vevo® micro-ultrasound systems are widely used by cancer researchers. Olive et al. used the Vevo high-resolution micro-ultrasound system to create images of normal and diseased tissue in mice as part of a pancreatic cancer study. The researchers also successfully used the Vevo MicroMarker microbubbles to see tumor perfusion.
Reviewed by Liji Thomas, MD

EFSUMB Educational Webinars Related to Ultrasound
Register at:
This webinar will be offered free of charge.
Participation at the webinar is limited to a maximum of 100 participants. Online registration will be closed upon reaching the maximum numbers of participants.
Early registration is recommended!
Event speakers:
Moderator: Yuko KONO, Department of Medicine, University of San Diego, USA
18:00 Yuko Kono Welcome address. ACR plans illustration. Webinar information.
18:05 Fabio Piscaglia. Rationale and role of the CEUS LI RADS project in the international guidelines arena in 2017.
18:30 Stephanie Wilson Definition and illustrations of the CEUS LI RADS classes.

EFSUMB WEBINAR events are made possible through the generous support of Bracco  

ICUS Sponsors

ICUS gratefully acknowledges its 2017 sponsors:






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