ICUS Weekly News Monitor 2-5-2016

1.  Ultrasound in Medicine and Biology,  Jan 28, 2016,  Acoustic Cluster Therapy: In Vitro and Ex Vivo Measurement of Activated Bubble Size Distribution and Temporal Dynamics
Authors: Andrew John Healey, et al
 
2.  Ultrasound in Medicine and Biology,  Jan 21, 2016,  Contrast-Enhanced Ultrasonography of Pancreatic Carcinoma: Correlation with Pathologic Findings     Authors:  Yanjie Wang, et al
 
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Ultrasound in Medicine and Biology
DOI: http://dx.doi.org/10.1016/j.ultrasmedbio.2015.12.011
 
Acoustic Cluster Therapy: In Vitro and Ex Vivo Measurement of Activated Bubble Size Distribution and Temporal Dynamics
 
Authors: Andrew John Healey;  Per Christian Sontum; Svein Kvåle; Morten Eriksen; Ragnar Bendiksen; Audun Tornes; Jonny Østensen
 
Correspondence:
Address correspondence to: Andrew John Healey, CSO, Phoenix Solutions AS, PO Box 4741, N-0421 Oslo, Norway.
 
Abstract
Acoustic cluster technology (ACT) is a two-component, microparticle formulation platform being developed for ultrasound-mediated drug delivery. Sonazoid microbubbles, which have a negative surface charge, are mixed with micron-sized perfluoromethylcyclopentane droplets stabilized with a positively charged surface membrane to form microbubble/microdroplet clusters. On exposure to ultrasound, the oil undergoes a phase change to the gaseous state, generating 20- to 40-μm ACT bubbles. An acoustic transmission technique is used to measure absorption and velocity dispersion of the ACT bubbles. An inversion technique computes bubble size population with temporal resolution of seconds. Bubble populations are measured both in vitro and in vivo after activation within the cardiac chambers of a dog model, with catheter-based flow through an extracorporeal measurement flow chamber. Volume-weighted mean diameter in arterial blood after activation in the left ventricle was 22 μm, with no bubbles >44 μm in diameter. After intravenous administration, 24.4% of the oil is activated in the cardiac chambers.
 
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Ultrasound in Medicine and Biology
DOI: http://dx.doi.org/10.1016/j.ultrasmedbio.2015.12.008
Jan 21, 2016
 
Contrast-Enhanced Ultrasonography of Pancreatic Carcinoma: Correlation with Pathologic Findings
Authors:  Yanjie Wang; Kun Yan; Zhihui Fan; Li Sun; Wei Wu; Wei Yang
 
Correspondence:
Address correspondence to: Kun Yan, Fucheng Road Number 52, District of Haidian, Beijing, China.
 
Abstract
We concluded that contrast-enhanced ultrasound (CEUS) has clinical value in identifying the pathologic changes of pancreatic carcinomas. Forty-three patients diagnosed with pancreatic carcinoma through surgery were retrospectively investigated. CEUS examinations were performed on all patients before surgery. Enhancement patterns on CEUS were observed. Time–intensity curves of CEUS were generated for the regions of interest in the pancreas, and quantitative parameters were obtained. Resected cancer specimens were stained with hematoxylin and eosin for histologic analysis, and the microvascular density (MVD) of the specimens was determined by CD34 immunohistochemical staining. Enhancement patterns of CEUS were compared with histopathologic findings in pancreatic carcinomas. Correlations between time–intensity curve parameters and microvascular density were analyzed. Twenty cases manifested centripetal enhancement, and 23 cases, global enhancement. The amount of tumor necrosis or mucus in the centripetally enhanced pancreatic carcinomas was greater than that in the globally enhanced pancreatic carcinomas (p = 0.027). Thirty-eight of 43 (88.4%) pancreatic carcinomas manifested hypo-enhancement with a maximum intensity (IMAX) <90%. Contrast arrival time in pancreatic carcinoma was longer than that in adjacent pancreatic tissue (p < 0.05). IMAX was positively correlated with microvascular density (r = 0.577, p < 0.05). We concluded that CEUS manifestations could reflect the histologic changes of pancreatic carcinomas and CEUS can be used to evaluate blood perfusion of tumors, as IMAX is positively correlated with microvascular density.

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