The Basics of Using Contrast

Category: About CEUS

Basics of Using CEUS

This recorded webinar was sponsored by the Intersocietal Accreditation Commission (IAC) and the American Society of Echcardiography (ASE), and may be viewed here:

Radiation from Alternative Imaging

Category: About CEUS

Ionizing radiation is used in several forms of diagnostic testing, such as X-ray imaging, computed tomography (CT or CAT scans), PET, radionuclide (nuclear medicine/SPECT) imaging, and angiography.  There is no radiation exposure from ultrasound (including CEUS) and magnetic resonance imaging (MRI).

All forms of diagnostic imaging may be useful tools for pinpointing disease and providing optimum medical care when medically indicated.  In many cases, the medical benefits of diagnostic tests may outweigh their inherent risks.  Nevertheless, radiation exposure from diagnostic imaging may increase cancer risk even at low levels, and may be cumulative over an individual’s lifetime.  According to the Joint Commission, which accredits health care programs in the US, exposure to ionizing radiation has nearly doubled over the past two decades, and physicians may order tests involving exposure to radiation “with no knowledge of when the patient was last irradiated or how much radiation the patient received.”

Diagnostic radiation is an effective tool that can save lives.  The higher the dose of radiation delivered at any one time, however, the greater risk for long-term damage. … The risks associated with the use of ionizing radiation in diagnostic imaging include cancer, burns and  other injuries.

Many experts now believe that ultrasound imaging (including CEUS) and MRI should be preferred where they would provide similar diagnostic information to radiation-based diagnostic exams.   According to the Joint Commission:

In order to reduce the exposure of the patient to ionizing radiation, use other imaging techniques, such as ultrasound or MRI, whenever these tests will produce the required diagnostic information at a similar quality level.

The following information describes concerns relating to radiation-based imaging.  Additional information on imaging tools follows.

Science Advisory - American Heart Association Committee on Cardiac Imaging 
of the Council on Clinical Cardiology and 
Committee on Cardiovascular Imaging and Intervention 
of the Council on Cardiovascular Radiology and Intervention

“Medical imaging is the largest controllable source of radiation exposure to the US population, and its most important determinant is the ordering healthcare provider.”

“Considerations should include options for answering the clinical question at hand by means that do not use ionizing radiation or choosing the type of study that exposes the patient to the lowest amount of radiation.”

“Therefore: Physician education should emphasize that cardiac imaging studies that expose patients to ionizing radiation should be ordered only after thoughtful consideration of the potential benefit to the patient and in keeping with established appropriateness criteria.”

Health care professionals are obligated to provide prudent advice that includes appropriate decisions regarding the implementation of high-yield, diagnostic imaging testing. Importantly, the associated, inherent risks must be considered when scheduling these imaging studies including the indiscriminate use of ionizing radiation.

The intrinsic value of performing a high quality TTE with contrast if clinically indicated must be viewed in the context of performing alternative or consecutive and comparable imaging studies.

If the TTE study is deemed inadequate for technical reasons, the patient is often referred for an additional test and includes additional risks which are as follows: (1) TEE has an associated risk of death of 1:10,000; (2) nuclear imaging test including Sestamibi = 9mSv or Thallium = 41 mSv imaging test; (3) CT-angiogram (mSv = 12-18), and (4) a coronary angiogram (2-16 mSv).

Thomas C. Gerber, J. Jeffrey Carr, Andrew E. Arai, Robert L. Dixon, Victor A. et al., Circulation Online Feb 2, 2009: DOI10.1161/CIRCULATIONAHA.108.1916502009

  • X-rays are invisible beams of ionizing radiation that create 2-dimensional images of various parts of the body, such as bones, lungs, and organ systems.  X-rays are not painful, and lead shields may decrease radiation exposure to areas that are not imaged.
  • CT scans use X-rays rotating around the body to create image “slices” that are transformed into 3-dimensional images.  CT provides superior data when compared to a single X-ray, but does so using more radiation.  Patients undergoing a CT scan are required to lie still on a table while the table moves through the CT scanner.  CT scans are painless but sedation may be required.  CT contrast agents are iodinated solutions that are administered intravenously to enhance visualization of organs and blood vessels.
  • PET (positron emission tomorgraphy) imaging uses injectable radionuclide (radioactive) agents that emit gamma ray signals measured by PET scanners.  PET is often used to detect and evaluate cancerous tumors, neurological conditions and cardiovascular disease.
  • Nuclear (SPECT) studies use small amounts of radioactive drugs that are administered intravenously and emit  gamma rays detected by a camera, which then converts the rays to electronic signals to create an image. The amount of radiation exposure depends on the type of study being performed.  SPECT studies are not painful, but require patients to lie still while images are being obtained.  Sedation may be required for some patients.
  • Angiography is an invasive procedure that produces X-ray images of the inside of blood vessels to evaluate blockages or other damage.  During an angiogram, a radio-opaque dye (which absorbs the x-rays) is injected into arteries using flexible catheter tubes and guide wires.   
  • MRI machines use powerful magnetic fields and radio-frequency transmitters to produce 3-dimensional images throughout the body, including the brain, muscles, heart and cancerous tumors.  MRI procedures do not expose patients to ionizing radiation.  While MRI scans are painless, some patients complain of claustrophobia and noise, and MRI contrast agents (gadolinium) used to enhance images may have associated risks.  In addition, pacemakers, implantable cardioverter-defibrillators, insulin pumps, cochlear implants, and certain other medical or biostimulation implants are generally considered contraindications for MRI imaging.  

 “Sentinel Event Alert,” August 24, 2011.  The Joint Commission (TJC), formerly the Joint Commission on Accreditation of Healthcare Organizations (JCAHO), accredits more than 19,000 health care organizations and programs in the United States.  See: HYPERLINK ""

Benefits of CEUS

Category: About CEUS

CEUS is often cheaper, safer, better, faster and more convenient than other forms of diagnostic imaging, and is performed without ionizing radiation. At a time of heightened concerns regarding overall health care costs and the cumulative impact of ionizing radiation due to medical diagnostic testing, CEUS is often an equivalent or superior means of diagnosing heart disease, pinpointing tumors, and evaluating other medical abnormalities throughout the body. Heres why:

Ultrasound contrast agents produce high-quality, reliable diagnostic images -- in fact, a CEUS stress echocardiogram is considered equivalent to a SPECT study for evaluation of coronary artery disease1.

Ultrasound contrast agents also are exceedingly safe. There is no statistically significant difference between the mortality rates of patients who receive ultrasound contrast and those who do not2. Moreover, unlike CT, PET, nuclear (SPECT) imaging, X-ray and angiography, CEUS does not expose patients to ionizing radiation, which can increase a patient’s lifetime risk of cancer. And ultrasound contrast agents do not contain dye, which can cause allergic reactions.

CEUS also may reduce costs of diagnostic imaging. Since an ultrasound contrast agent often salvages suboptimal studies by “significantly” improving interpretability3, CEUS reduces the need for redundant, more expensive, and sometimes riskier downstream diagnostic testing. And ultrasound equipment is significantly cheaper than other forms of diagnostic imaging equipment (including equipment used in MRI, CT and angiography) -- and does not require the construction of expensive dedicated imaging suites. Moreover, ultrasound equipment is portable and widely available, and may be brought to the bedside of a patient who cannot get to a CT or MRI scanner.

And CEUS provides immediate information in varied settings. As recognized by the new European CEUS “Guidelines and Recommendations”4:

CEUS has a number of distinct advantages over CT and MRI. It can be performed immediately, without any preliminary laboratory testing, and it can be carried out in a variety of scenarios (bedside, operating room, CT suite, etc.). Importantly also, it opertes in real time so that rapid changes can be captured.

Considered a “revolutionary technique” with “exponentially increasing interest,” CEUS may be used safely in nearly all organ systems, according to the introduction to the Guidelines.

In sum, CEUS advantages include the following:

  • Accurate and reliable diagnoses
  • Strong safety profile
  • No ionizing radiation (as in SPECT, CT, PET, angiography and X-ray)
  • No iodinated dye (as in CT or X-ray contrast agents)
  • No invasive catheterization
  • No risk of nephrotoxicity
  • No anesthesia or sedation (as may be required with CT, MRI or angiography)
  • Fewer redundant, unnecessary downstream tests
  • Lowers overall costs
  • Cheaper equipment -- no “big box” imaging machines or dedicated suites
  • Convenient and easy to use
  • Portable - may be used at patient’s bedside
  • May be used to image growing number of severely obese patients
  • Potential for screening, prevention, and ongoing monitoring of care
  • Widespread international acceptance

Are there risks associated with CEUS?

Yes, and product labeling should be examined and followed. However, studies indicate that risks associated with CEUS use are quite low when compared to risks associated with other widely accepted imaging tools. For example, recent scientific reports show no increased mortality or safety signal even among the sickest patients.

Information on product labels and safety studies may be found elsewhere on this website.

ICUS Sponsors

ICUS gratefully acknowledges its 2017 sponsors:






Contact ICUS

  • Address:  International Contrast Ultrasound Society
    c/o Dentons
    233 S. Wacker Drive, Suite 5900 Chicago, IL 60606-6361
  • Telephone: 202-408-6199

About ICUS

ICUS is the world’s only professional society exclusively devoted to contrast-enhanced ultrasound (CEUS) medical imaging technology.

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